Association of central and peripheral pulse pressure with intermediate cardiovascular phenoytpes
| Autor: | Christian Delles, Chiara Taurino, Faiez Zannad, Łukasz Klima, John D. McClure, Cédric Collin, Laura Lonati, Enrico Agabiti Rosei, Tatiana Kuznetsova, Maria Lorenza Muiesan, Kalina Kawecka-Jaszcz, Fernando Martinez, Josep Redon, Olle Melander, Ulf Neisius, Alberto Zanchetti, Patrick Rossignol, Grzegorz Bilo, Jan A. Staessen, Anna F. Dominiczak, M. Schneider, Katarzyna Stolarz-Skrzypek, Stéphane Laurent |
|---|---|
| Přispěvatelé: | Neisius, U, Bilo, G, Taurino, C, Mcclure, J, Schneider, M, Kawecka Jaszcz, K, Stolarz Skrzypek, K, Klima, Å, Staessen, J, Kuznetsova, T, Redon, J, Martinez, F, Rosei, E, Muiesan, M, Melander, O, Zannad, F, Rossignol, P, Laurent, S, Collin, C, Lonati, L, Zanchetti, A, Dominiczak, A, Delles, C |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Physiology intermediate cardiovascular phenotypes Blood Pressure 030204 cardiovascular system & hematology surrogate markers Cohort Studies pressure 0302 clinical medicine Heart Rate pulse wave analysis 030212 general & internal medicine risk-factors stage renal-disease Pulse wave velocity pulse wave analysi Middle Aged Phenotype Peripheral Pulse pressure left ventricular hypertrophy arterial stiffness aortic pressure Aortic pressure Cardiology all-cause mortality Female Cardiology and Cardiovascular Medicine Human Adult medicine.medical_specialty Mean arterial pressure hypertension collaborative trial acct pulse wave velocity intimamedia thickness Humans Hypertension Internal Medicine brachial blood-pressure wave reflection steady component 03 medical and health sciences intermediate cardiovascular phenotype Internal medicine Heart rate medicine intima-media thickness intimamedia thickne business.industry medicine.disease Blood pressure Intima-media thickness Arterial stiffness Cohort Studie business |
| Zdroj: | Journal of Hypertension Journal of Hypertension; Vol 30 |
| Popis: | Objective: We assessed the relationship between pulse pressure and intermediate cardiovascular phenotypes in a middle-aged cohort with high prevalence of hypertension. Background: It has been suggested that central pulse pressure (cPP) is a better predictor of cardiovascular outcome than peripheral pulse pressure (pPP), particularly in the elderly. Yet, it is unclear if cPP provides additional prognostic information to pPP in younger individuals. Methods: In 535 individuals we assessed cPP and pPP as well as the intermediate cardiovascular phenotypes pulse wave velocity (PWV; SphygmoCor, Complior, PulsePen), carotid intima-media thickness (C-IMT; carotid ultrasound), left-ventricular mass index (LVMI; echocardiography) and urinary albumin : creatinine ratio (ACR). cPP was derived noninvasively from brachial blood pressure by pulse wave analysis (PWA; SphygmoCor) based on radial pulse wave tonometry and a validated transfer function. Results: The cohort contained 331 hypertensive participants of whom 84% were treated. The average age was 46 ± 16 years. When compared to pPP, cPP had stronger associations with PWV (r = 0.471 vs. r = 0.372; P < 0.01), C-IMT (r = 0.426 vs. r = 0.235; P < 0.01) and LVMI (r = 0.385 vs. r = 0.189; P < 0.01), but equal association with ACR (r = 0.236 vs. r = 0.226; P = n.s.). In contrast, after adjustment for age, mean arterial pressure, heart rate and hypertension status there was no significant difference between cPP and pPP for prediction of PWV (adjusted R, 0.399 vs. 0.413; P = 0.066), C-IMT (adjusted R, 0.399 vs. 0.413; P = 0.487) and LVMI (adjusted R 2, 0.181 vs. 0.170; P = 0.094) in multivariate analysis. Conclusion: In our middle-aged cohort with high prevalence of hypertension cPP is more closely correlated with cardiovascular phenotypes than pPP. When adjusted for relevant cofactors, however, cPP does not provide additional information beyond pPP. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|