Association between Potentially Inappropriate Medication Use and Chronic Diseases in the Elderly

Autor: Hai-Lin Lu, Pou-Jen Ku, Tzu-Chueh Wang, Hue-Yu Wang, Damien Trezise, Kung-Chuan Hsu
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Drug
medicine.medical_specialty
Health
Toxicology and Mutagenesis
media_common.quotation_subject
Population
Beers Criteria
lcsh:Medicine
Comorbidity
Urinalysis
030226 pharmacology & pharmacy
elderly
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
hemic and lymphatic diseases
Odds Ratio
Prevalence
medicine
Humans
Glycoside Hydrolase Inhibitors
030212 general & internal medicine
Potentially Inappropriate Medication
Medical prescription
Adverse effect
education
Potentially Inappropriate Medication List
Aged
media_common
Aged
80 and over
Medication use
education.field_of_study
business.industry
lcsh:R
Infant
Newborn
Public Health
Environmental and Occupational Health
Odds ratio
humanities
Confidence interval
Cross-Sectional Studies
Liver
Female
Independent Living
business
chronic disease
Zdroj: International Journal of Environmental Research and Public Health, Vol 16, Iss 12, p 2189 (2019)
International Journal of Environmental Research and Public Health
Volume 16
Issue 12
ISSN: 1660-4601
Popis: Long-term continuous exposure to potentially inappropriate medications (PIMs) can lead to adverse events in the elderly. However, the effects of long-term exposure of the elderly to PIM and the relationship between PIM and chronic diseases remain unclear. The objective of this study was to investigate the continuous use of PIMs in a community-dwelling elderly population. A cross-sectional population-based study was conducted using community pharmacy&ndash
filed dispensing records from the Hcare system. Twenty-three community pharmacies were sampled from 2013 to 2015 to obtain records of patients above 65 years-old with continuous prescriptions. PIM were identified according to the 2015 Beers Criteria. The prevalence of patients using PIM was highest in patients with co-morbid mental disorders (40.05%), followed by neurological system disorders (28.91%). Patients who were prescribed a PIM were more than three times as likely to have a mental disorder as those (odds ratio 3.16, 95% confidence interval: 3.06&ndash
3.28) with non-chronic diseases. The most prescribed PIM agents were central nervous system drugs (53.16%), and benzodiazepines (35.15%). Patients with mental disorders had the highest rate of long-term persistent PIM exposure, with benzodiazepines being the most frequently dispensed. Drug safety concerns should be closely monitored in elderly patients with the abovementioned conditions.
Databáze: OpenAIRE
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