Detecting Task Functional MRI Activation Using the Multiband Multiecho (MBME) Echo-Planar Imaging (EPI) Sequence
| Autor: | Brice Fernandez, Amritpal S. Jagra, Alexander D. Cohen, Baolian Yang, Suchandrima Banerjee, Yang Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Computer science Intraclass correlation Population computer.software_genre 030218 nuclear medicine & medical imaging Task (project management) 03 medical and health sciences Young Adult 0302 clinical medicine Sørensen–Dice coefficient Voxel medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies education Echo-planar imaging education.field_of_study Brain Mapping Blood-oxygen-level dependent Echo-Planar Imaging Brain Reproducibility of Results Middle Aged Magnetic Resonance Imaging Visual cortex medicine.anatomical_structure Female computer Biomedical engineering |
| Zdroj: | Journal of magnetic resonance imaging : JMRIReferences. 53(5) |
| ISSN: | 1522-2586 |
| Popis: | BACKGROUND Blood oxygen level-dependent (BOLD) functional MRI (fMRI) has been widely applied to detect brain activations. Recent advances in multiband (MB) and multiecho (ME) techniques have greatly improved fMRI methods. MB imaging improves temporal and/or spatial resolution, while ME imaging has been shown to improve BOLD sensitivity. This study aimed to evaluate the novel MBME echo planar imaging (EPI) sequence utilizing MB and ME simultaneously to determine if the MBME outperform the MB single echo (MBSE) sequence for task fMRI. PURPOSE To compare the performance of MBME with MBSE in a task fMRI study. STUDY TYPE Prospective. POPULATION A total of 29 healthy volunteers aged 20-46 years (9 male, 20 female). FIELD STRENGTH/SEQUENCE MBSE and MBME gradient-echo EPI sequences were applied at 3T. Additional T1 -weighted magnetization-prepared rapid acquisition with gradient echo (MPRAGE) was collected. ASSESSMENT A checkerboard visual task was presented during the functional MBSE and MBME scans. The MBME or MBSE signal was evaluated using the temporal signal-to-noise ratio (tSNR). Task activation was evaluated using the z-score, volume, sensitivity, and specificity. Test-retest metrics of task activation were examined with the Dice coefficient (DC) and intraclass correlation coefficient (ICC) on subjects with repeated scans. STATISTICAL TESTS A linear mixed-effects model was used to compared MBME and MBSE activation at the voxel base. The paired t-test was used to compare tSNR, activation z-score, and volume, along with sensitivity, specificity, and DC between MBSE and MBME. RESULTS While similar task activation was detected in the visual cortex, MBME showed higher activation volume and higher sensitivity compared with MBSE (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text