Formation of a novel bicyclic γ-lactam with isopenicillin N synthase

Autor:	Jack E. Baldwin, Jonathan Michael Blackburn, Christopher J. Schofield, Magoichi Sako
Rok vydání:	1989
Předmět:	chemistry.chemical_compound biology Bicyclic molecule chemistry Stereochemistry Intramolecular force polycyclic compounds Isopenicillin N synthase biology.protein Lactam Molecular Medicine
Zdroj:	J. Chem. Soc., Chem. Commun.. :970-972
ISSN:	0022-4936
Popis:	Incubation of isopenicillin N synthase (IPNS) with [(5S)-5-amino-5- carboxypentanoyl]-L- homocysteinyl-L-cysteine (14) resulted in the formation of a novel bicyclic γ-lactam (17) containing an intramolecular disulphide linkage.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c5b8a895d2ac76abee86deb1b201c4 https://doi.org/10.1039/c39890000970 Zobrazit plný text záznamu