Effect of moonseed vine (Triclisia gilletii Staner) on ethane-1,2-diol-induced urolithiasis and its renotoxicity in Wistar albino rats
| Autor: | Afolabi C. Akinmoladun, Olusola Olalekan Elekofehinti, Olanrewaju Sam Olayeriju, Akintunde Afolabi Akindahunsi, Olamide O. Crown, Mary Tolulope Olaleye |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Urology
Diol 030232 urology & nephrology Calcium oxalate Oxidative phosphorylation Nephrolithiasis lcsh:RC870-923 Oxalate Triclisia gilletii 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine Phenols 030304 developmental biology chemistry.chemical_classification Inflammation 0303 health sciences biology Traditional medicine Electrolyte imbalance business.industry biology.organism_classification lcsh:Diseases of the genitourinary system. Urology Enzyme chemistry Decreased glomerular filtration rate Oxidative stress Triclisia business Nephroprotectant |
| Zdroj: | African Journal of Urology, Vol 26, Iss 1, Pp 1-16 (2020) |
| ISSN: | 1961-9987 1110-5704 |
| Popis: | BackgroundMoonseed vine (Triclisia gilletiiStaner) in the family Menispermaceae is a robust creeper of up to 10 cm diameter, of the lowland dense rain forest. In Ondo State, located in the South Western part of Nigeria, the plant which is usually called Peshe is used for the management of renal-related ailments. The present study was undertaken to explore the efficacy ofTriclisia gilletii, a folkloric therapy in the management of renal-related ailment.ResultsPhenols, steroids, saponins, and flavonoids are present in the TGME with a total antioxidant capacity of (30.36 ± 1.90 (mg GAE/g extract), LD50greater than 5000 mg/kg b.w., and in vitro anti-nucleation activity (iC50 = 7.09 mg/mL). Calcium oxalate stone formation as a result of oxalate from ethane-1,2-diol was evident by hypocalcemia, and further electrolyte imbalance and decreased glomerular filtration rate. The enhanced oxidative milieu in hyperoxaluria was evident by increased MDA and PC and decreased enzymatic and non-enzymatic antioxidants as well as renal membrane enzymes activities. The renal histopathological study further emphasized oxalate-induced damage and the ameliorative potential of TGME.ConclusionThe abnormal biochemical, redox electrolyte, membrane integrity, and histological alterations were attenuated by TGME which affirms its usage as nephroprotectant. |
| Databáze: | OpenAIRE |
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