More inflammation but less brain-derived neurotrophic factor in antisocial personality disorder

Autor:	Ming Chuan Hu, Yun Hsuan Chang, Sheng Yu Lee, Shiou Lan Chen, I. Hui Lee, Po See Chen, Chia Ling Li, Shih Hsien Lin, Jau-Shyong Hong, Yen Kuang Yang, Tzu Yun Wang, Chun Hsien Chu, Liang-Jen Wang, Kao Chin Chen, Ru Band Lu, San Yuan Huang, Nian-Sheng Tzeng, Shih Heng Chen
Rok vydání:	2017
Předmět:	Adult Male 0301 basic medicine Oncology medicine.medical_specialty Substance-Related Disorders Endocrinology Diabetes and Metabolism Inflammation Comorbidity behavioral disciplines and activities Proinflammatory cytokine Transforming Growth Factor beta1 Pathogenesis 03 medical and health sciences 0302 clinical medicine Endocrinology Neurotrophic factors Internal medicine mental disorders medicine Humans health care economics and organizations Biological Psychiatry Brain-derived neurotrophic factor Tumor Necrosis Factor-alpha Endocrine and Autonomic Systems Brain-Derived Neurotrophic Factor Antisocial personality disorder Confounding Opioid use disorder Antisocial Personality Disorder Middle Aged Opioid-Related Disorders medicine.disease humanities Interleukin-10 Psychiatry and Mental health C-Reactive Protein 030104 developmental biology behavior and behavior mechanisms medicine.symptom Psychology 030217 neurology & neurosurgery Clinical psychology
Zdroj:	Psychoneuroendocrinology. 85:42-48
ISSN:	0306-4530
Popis:	Antisocial personality disorder (ASPD) is highly comorbid with substance use disorders (SUDs). We hypothesize that chronic neuroinflammation and the loss of neurotrophic factors prompts the pathogenesis of both disorders. We used ELISA to measure plasma levels of proinflammatory (tumor necrosis factor-α [TNF-α], C-reactive protein [CRP]) and anti-inflammatory factors (transforming growth factor-β1 [TGF-β1] and interleukin-10 [IL-10]), and brain-derived neurotrophic factor (BDNF) in male patients with ASPD (n=74), SUDs (n=168), ASPD comorbid with SUDs (ASPD+SUDs) (n=438), and Healthy Controls (HCs) (n=81). A multivariate analysis of covariance (MANCOVA) controlled for possible confounders was used to compare cytokines and BDNF levels between groups. The results of MANCOVA adjusted for age showed a significant (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c308ea7cfdb09b8ac45b402f4fd150 https://doi.org/10.1016/j.psyneuen.2017.08.006 Zobrazit plný text záznamu Full Text from ScienceDirect