The effect of amantadine on levodopa-induced dyskinesias in Parkinson's disease: a double-blind, placebo-controlled study
| Autor: | David Mcauley, Barry Snow, Lorraine Macdonald, William Wallis |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Levodopa Dyskinesia Drug-Induced Parkinson's disease Placebo-controlled study Placebo Antiparkinson Agents Double-Blind Method mental disorders otorhinolaryngologic diseases medicine Amantadine Humans Pharmacology (medical) Aged Pharmacology Cross-Over Studies business.industry Parkinsonism Parkinson Disease Middle Aged medicine.disease Crossover study nervous system diseases Dyskinesia Anesthesia Drug Therapy Combination Female Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Clinical neuropharmacology. 23(2) |
| ISSN: | 0362-5664 |
| Popis: | We performed a double-blind, placebo-controlled, crossover study to assess the effect of amantadine versus placebo on levodopa-induced dyskinesias in Parkinson's disease. We found a 24% reduction in the total dyskinesia score after amantadine administration (p = 0.004). This improvement was achieved without any influence on the severity of "on" period parkinsonism. The results confirm that amantadine reduces levodopa dyskinesias and support the hypothesis that dyskinesias can be reduced by blockade of excitatory pathways in the basal ganglia. |
| Databáze: | OpenAIRE |
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