Association between vascular endothelial growth factor and hypertension in children and adolescents type I diabetes mellitus

Autor: Karolina Rybarczyk-Kapturska, Ewa Malinowska, Krystyna Raczyńska, Jolanta Myśliwska, Małgorzata Myśliwiec, Piotr Wiśniewski, Katarzyna Zorena
Rok vydání: 2010
Předmět:
Male
Vascular Endothelial Growth Factor A
medicine.medical_specialty
Adolescent
endocrine system diseases
microangiopathy
Blood Pressure
Enzyme-Linked Immunosorbent Assay
Risk Assessment
Gastroenterology
Young Adult
chemistry.chemical_compound
Blood serum
Risk Factors
Internal medicine
Internal Medicine
medicine
Albuminuria
Humans
type I diabetes
Child
Glycated Hemoglobin
Type 1 diabetes
Diabetic Retinopathy
business.industry
Incidence
Microangiopathy
nutritional and metabolic diseases
Diabetic retinopathy
medicine.disease
VEGF
Vascular endothelial growth factor
Diabetes Mellitus
Type 1
Blood pressure
Endocrinology
children and adolescents
chemistry
Case-Control Studies
Hypertension
Disease Progression
Linear Models
Original Article
Female
Microalbuminuria
Poland
business
Biomarkers
Retinopathy
Zdroj: Journal of Human Hypertension
ISSN: 1476-5527
0950-9240
DOI: 10.1038/jhh.2010.7
Popis: The aim of the study was to analyse the relationship between the serum level of vascular endothelial growth factor (VEGF) and the incidence of hypertension (HT) in children and adolescents with type I diabetes mellitus (T1DM). One hundred and five patients with T1DM were enrolled in the study. The control group consisted of 30 healthy controls. All the T1DM patients were subjected to biochemical analyses, ophthalmologic examination and 24-h blood pressure monitoring. Besides, all the patients and healthy controls had serum VEGF levels measured with the use of the ELISA methodology. The essence of our research is that patients with T1DM and HT and with microalbuminuria (MA) and diabetic retinopathy (DR) (MA/DR) are characterized by a significantly higher level of VEGF (340.23±93.22 pg ml(-1)) in blood serum in comparison with the group of T1DM patients without HT and MA/DR (183.6±96.6 pg ml(-1)) and with healthy controls (145.32±75.58 pg ml(-1)). In addition, the VEGF level was significantly higher in T1DM patients, who presented all three complications, that is HT, retinopathy and MA in comparison with T1DM patients without HT, but with MA/DR (P=0.036). On the other hand, no statistically significant differences (P=0.19) were noted in the level of VEGF in serum between T1DM patients without HT and MA/DR and the healthy control group. At a further stage of analysis, using the method of multiple regression, it was shown that systolic pressure, HbA1c and duration of disease are independent factors influencing the concentration of VEGF. Summarizing, the measurement of VEGF serum levels allows for the identification of groups of patients who have the highest risk of HT and, subsequently, progression of vascular complications.
Databáze: OpenAIRE
Externí odkaz: