Effects of negative pressure wound therapy on cellular energetics in fibroblasts grown in a provisional wound (fibrin) matrix
| Autor: | Patricia A. Villanueva, Kris Kieswetter, Amy K. McNulty, Teri D. Feeley, Marisa Schmidt |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Cell Culture Techniques Alpha (ethology) Occlusive Dressings Dermatology Pharmacology Statistics Nonparametric Electron Transport Complex IV chemistry.chemical_compound Adenosine Triphosphate Transforming Growth Factor beta Negative-pressure wound therapy medicine Humans Cytochrome c oxidase Energy charge Cells Cultured Platelet-Derived Growth Factor Analysis of Variance Fibrin Wound Healing biology Growth factor Fibroblasts Surgery Adenosine Diphosphate Adenosine diphosphate chemistry Granulation Tissue biology.protein Intercellular Signaling Peptides and Proteins Wounds and Injuries Energy Metabolism Wound healing Adenosine triphosphate Negative-Pressure Wound Therapy |
| Zdroj: | Wound Repair and Regeneration. 17:192-199 |
| ISSN: | 1524-475X 1067-1927 |
| DOI: | 10.1111/j.1524-475x.2009.00460.x |
| Popis: | Negative pressure wound therapy (NPWT) using reticulated open cell foam dressing (ROCF) is effective for treatment of recalcitrant wounds; however, the effects of this therapy on cellular metabolism remain to be elucidated. The effect of two different subatmospheric pressure applications on the cell energetics of human fibroblasts grown in a 3D fibrin matrix was studied using two different pressure-manifolding materials, an ROCF or gauze under suction (GUS). It was found that levels of cytochrome c oxidase, energy charge, and adenosine triphosphate/adenosine diphosphate were significantly increased following the application of NPWT using ROCF vs. GUS (p |
| Databáze: | OpenAIRE |
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