Clinical Features of Asymptomatic SARS-CoV-2 Infection in Hemodialysis Patients
| Autor: | Alejandro Avello, Teresa Stock da Cunha, Elena Gomá-Garcés, Sebastian Mas-Fontao, Maria Soledad Pizarro-Sánchez, Monica Pereira, Alberto Ortiz, E. Gonzalez-Parra |
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| Rok vydání: | 2021 |
| Předmět: |
Male
lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_specialty medicine.medical_treatment 030232 urology & nephrology Disease lcsh:RC870-923 Asymptomatic Serology 03 medical and health sciences 0302 clinical medicine Renal Dialysis Chronic kidney disease Internal medicine Troponin I Epidemiology lcsh:Dermatology medicine Humans Mortality Renal Insufficiency Chronic Risk factor Aged Retrospective Studies Aged 80 and over business.industry Brief Report COVID-19 Retrospective cohort study General Medicine lcsh:RL1-803 Middle Aged lcsh:Diseases of the genitourinary system. Urology lcsh:RC666-701 Nephrology Hemodialysis Asymptomatic Diseases Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Kidney & Blood Pressure Research Kidney & Blood Pressure Research, Vol 46, Iss 1, Pp 126-134 (2021) |
| ISSN: | 1423-0143 1420-4096 |
| Popis: | Background: CKD is a risk factor for severe COVID-19. However, the clinical spectrum of COVID-19 in hemodialysis patients is still poorly characterized. Objective: To analyze the clinical spectrum of COVID-19 on hemodialysis patients. Method: A retrospective observational study was conducted on 66 hemodialysis patients. Nasopharyngeal swab PCR and serology for SARS-CoV-2, blood analysis, chest radiography, treatment, and outcomes were assessed. Results: COVID-19 was diagnosed in 50 patients: 38 (76%) were PCR-positive and 12 (24%) were PCR-negative but developed anti-SARS-CoV-2 antibodies. By contrast, 17% of PCR-positive patients failed to develop detectable antibodies against SARS-CoV-2. Among PCR-positive patients, 5/38 (13%) were asymptomatic, while among PCR-negative patients 7/12 (58%) were asymptomatic (p = 0.005) for a total of 12/50 (24%) asymptomatic patients. No other differences were found between PCR-positive and PCR-negative patients. No differences in potential predisposing factors were found between asymptomatic and symptomatic patients except for a lower use of ACE inhibitors among asymptomatic patients. Asymptomatic patients had laboratory evidence of milder disease such as higher lymphocyte counts and oxygen saturation and lower troponin I and interleukin-6 levels than symptomatic patients. Overall mortality was 7/50 (14%) and occurred only in symptomatic PCR-positive patients in whom mortality was 7/33 (21%). Conclusions: Asymptomatic SARS-CoV-2 infection is common in hemodialysis patients, especially among patients with initial negative PCR that later seroconvert. Thus COVID-19 mortality in hemodialysis patients may be lower than previously estimated based on PCR tests alone. |
| Databáze: | OpenAIRE |
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