Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries)
| Autor: | Joram M. Mwacharo, Mourad Rekik, Barbara Rischkowsky, David Wragg, Negar Khayatzadeh, Asrat Tera Dolebo, Aberra Melesse, Max F. Rothschild, Aynalem Haile |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Offspring
media_common.quotation_subject Fertility Genome-wide association study Quantitative trait locus Biology Article 03 medical and health sciences Quantitative Trait Heritable Genetics Animals Cluster Analysis Protein Interaction Maps Gene Ovis Africa South of the Sahara 030304 developmental biology media_common 0303 health sciences Principal Component Analysis Sheep Reproductive success Reproduction 0402 animal and dairy science 04 agricultural and veterinary sciences biology.organism_classification 040201 dairy & animal science Haplotypes Evolutionary biology Genome-Wide Association Study |
| Zdroj: | Mammalian Genome Dolebo, A, Khayatzadeh, N, Melesse, A, Wragg, D, Rekik, M, Haile, A, Rischkowsky, B, Rothschild, M F & Mwacharo, J M 2019, ' Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries) ', Mammalian Genome, vol. 30, no. 11-12, pp. 339-352 . https://doi.org/10.1007/s00335-019-09820-5 |
| ISSN: | 1432-1777 0938-8990 |
| Popis: | Maximizing the number of offspring born per female is a key functionality trait in commercial- and/or subsistence-oriented livestock enterprises. Although the number of offspring born is closely associated with female fertility and reproductive success, the genetic control of these traits remains poorly understood in sub-Saharan Africa livestock. Using selection signature analysis performed on Ovine HD BeadChip data from the prolific Bonga sheep in Ethiopia, 41 candidate regions under selection were identified. The analysis revealed one strong selection signature on a candidate region on chromosome X spanningBMP15, suggesting this to be the primary candidate prolificacy gene in the breed. The analysis also identified several candidate regions spanning genes not reported before in prolific sheep but underlying fertility and reproduction in other species. The genes associated with female reproduction traits includedSPOCK1(age at first oestrus),GPR173(mediator of ovarian cyclicity),HB-EGF(signalling early pregnancy success) andSMARCAL1andHMGN3a(regulate gene expression during embryogenesis). The genes involved in male reproduction wereFOXJ1(sperm function and successful fertilization) andNME5(spermatogenesis). We also observed genes such asPKD2L2,MAGED1andKDM3B, which have been associated with diverse fertility traits in both sexes of other species. The results confirm the complexity of the genetic mechanisms underlying reproduction while suggesting that prolificacy in the Bonga sheep, and possibly African indigenous sheep is partly under the control ofBMP15while other genes that enhance male and female fertility are essential for reproductive fitness. |
| Databáze: | OpenAIRE |
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