Population distribution profiles of the activities of blood alanine and aspartate aminotransferase in the normal F344 inbred rat by age and sex
| Autor: | Abraham Nyska, Trevor Waner, Rina Chen |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Aging medicine.medical_specialty Population Normal Distribution F344 rats Biology Age and sex digestive system Reference Values Internal medicine medicine Animals Distribution (pharmacology) Aspartate Aminotransferases Alanine aminotransferase education Alanine chemistry.chemical_classification Sex Characteristics education.field_of_study General Veterinary Alanine Transaminase Rats Inbred F344 digestive system diseases Rats Endocrinology Enzyme Biochemistry chemistry Toxicity Female Animal Science and Zoology |
| Zdroj: | Laboratory Animals. 25:263-271 |
| ISSN: | 1758-1117 0023-6772 |
| DOI: | 10.1258/002367791780808275 |
| Popis: | Data on the blood enzyme activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were collected from control male and female F344 rats participating in toxicity studies at 17, 30, 56, 80 and 106 weeks of age. The data were skewed to the right with significant deviation from normality. Applying the Box-Cox transformation, it was concluded that approximately normal distributions could be obtained by using the reciprocal transformation. In general, the males showed a greater degree of heterogeneity for both enzymes. Enzyme activities at 17 weeks were lowest for both ALT and AST. There was a high correlation between the activities of blood ALT and AST, with some animals showing dramatic transient increases. Significant differences among studies with respect to the enzyme activities in rats of the same age were demonstrated. |
| Databáze: | OpenAIRE |
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