Repeated valproate treatment facilitates fear extinction under specific stimulus conditions
| Autor: | Gary B. Kaplan, Ann M. Rasmusson, Kimberly A. Leite-Morris, Stephen C. Heinrichs |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Time Factors medicine.drug_class Conditioning Classical Pharmacology Stimulus (physiology) Extinction Psychological Developmental psychology Mice chemistry.chemical_compound Single dose treatment medicine Animals natural sciences Short duration Valproic Acid General Neuroscience Histone deacetylase inhibitor Sodium butyrate Fear social sciences Extinction (psychology) musculoskeletal system humanities Histone Deacetylase Inhibitors chemistry Butyric Acid Psychology geographic locations medicine.drug |
| Zdroj: | Neuroscience Letters. 552:108-113 |
| ISSN: | 0304-3940 |
| Popis: | Single dose treatment with histone deacetylase inhibitor (HDACi) agents has been shown to enhance extinction learning in rodent models under certain conditions. The present novel studies were designed to examine the effects of repeated HDACi treatment, with valproate or sodium butyrate, on the extinction of conditioned fear. In Experiments 1 and 2, short duration CS exposure (30s) in combination with vehicle administration progressively attenuated conditioned fear responses over 40 or more sessions. This effective extinction training was not augmented by HDACi treatments. In Experiment 3, we used a long duration CS exposure (120 s) to weaken extinction training. With these extinction parameters, repeated valproate treatment substantially facilitated the acquisition and retention of fear extinction. Results of this study extend previous work suggesting that HDACi's have utility in augmenting the efficiency of fear extinction, although their apparent benefits are critically dependent upon specific parameters of extinction training. |
| Databáze: | OpenAIRE |
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