TISSUE TRANSGLUTAMINASE: A MEDIATOR AND PREDICTOR OF CHRONIC ALLOGRAFT NEPHROPATHY?
| Autor: | Samantha Bex, C B Brown, James Skill, Hamdy Abo-Zenah, Graham Wild, Martin Griffin, A. Meguid El Nahas, Timothy S. Johnson |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Tissue transglutaminase Kidney Gastroenterology Nephropathy GTP-Binding Proteins Chronic allograft nephropathy Internal medicine Renal fibrosis medicine Humans Transplantation Homologous Protein Glutamine gamma Glutamyltransferase 2 Tissue Distribution Postoperative Period Homologous transplantation Transplantation Transglutaminases Staining and Labeling biology medicine.diagnostic_test business.industry Extracellular Fluid Dipeptides Middle Aged Prognosis medicine.disease Kidney Transplantation Treatment Outcome medicine.anatomical_structure Solubility Chronic Disease Immunologic Techniques biology.protein Female Kidney Diseases Renal biopsy business |
| Zdroj: | Transplantation. 77:1667-1675 |
| ISSN: | 0041-1337 |
| Popis: | Background. The precise mechanisms underlying the development of chronic allograft nephropathy (CAN) and the associated renal fibrosis remain uncertain. The protein-crosslinking enzyme, tissue transglutaminase (tTg), has recently been implicated in renal fibrosis. Methods. We investigated the involvement of tTg and its crosslink product, [epsilon]-([gamma]-glutamyl) lysine, in 23 human kidney allografts during the early posttransplantation period and related these to changes of CAN that developed in 8 of them. Sequential biopsies were investigated using immunohistochemical, immunofluorescence, and in situ enzyme activity techniques. Results. From implantation, tTg (+266%) and [epsilon]-([gamma]-glutamyl) lysine crosslink (+256.3%) staining increased significantly (P |
| Databáze: | OpenAIRE |
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