Mu-Opioid Receptor Expression in Laryngeal Cancer
| Autor: | Monica Huszar, Juan P. Cata, Oded Cohen, Iris Levy, Yonatan Lahav, Doron Halperin, Hagit Shoffel-Havakuk |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Glottis business.industry Head and neck cancer Cell Cancer LPN and LVN medicine.disease Staining 030507 speech-language pathology & audiology 03 medical and health sciences Speech and Hearing 0302 clinical medicine medicine.anatomical_structure Otorhinolaryngology medicine Carcinoma Immunohistochemistry 030223 otorhinolaryngology 0305 other medical science business Receptor |
| Zdroj: | Journal of voice : official journal of the Voice Foundation. |
| ISSN: | 1873-4588 |
| Popis: | Summary Objectives Expression of mu-opioid receptors (MORs) has not been investigated in head and neck cancer. In this study, we aimed to assess the expression of opioids receptors in laryngeal cancer, compared to adjacent non-malignant tissue. Study design A retrospective case series in a single academic center. Methods Sixty-four specimens were taken from 32 matched patients, diagnosed with laryngeal-carcinoma (20 supraglottic and 12 glottic), and were analyzed using immunohistochemical stains for MOR. All sections were examined and evaluated with a semi-quantitative analysis for staining intensity and cell count for a percentage of the positively stained cells. Survival of patients was compared based on MOR expression. Results MOR staining intensity was significantly increased in laryngeal-carcinoma compared to the normal tissue adjacent to the carcinoma (P = 0.019). The percentage of stained cells in non-involved supraglottis was significantly higher compared to the non-involved glottis (P = 0.022), yet this difference was no longer found between supra- and glottic-carcinoma tissues. Conclusion MOR may play a role in the laryngeal cancer environment, as the expression in tumor cells alters from adjacent non-cancerous tissue. |
| Databáze: | OpenAIRE |
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