Antiproliferative activity of a series of novel cyclopropyl antiestrogens on MCF-7 human breast cancer cells in culture
| Autor: | Graves Dc, Jain Pt, J T Pento, Magarian Ra |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Cyclopropanes
Oncology Cancer Research medicine.medical_specialty Estrogen receptor Antineoplastic Agents Breast Neoplasms chemistry.chemical_compound Breast cancer Hemocytometer Internal medicine Benzene Derivatives Tumor Cells Cultured medicine Humans Pharmacology (medical) Pharmacology Antitumor activity Estradiol Chemistry Estrogen Antagonists medicine.disease Receptors Estrogen MCF-7 Cancer cell Cancer research Female Trypan blue Human breast Cell Division |
| Zdroj: | Anti-Cancer Drugs. 2:487-494 |
| ISSN: | 0959-4973 |
| DOI: | 10.1097/00001813-199110000-00009 |
| Popis: | The potential antitumor activity of a series of novel cyclopropyl compounds, which lack estrogen agonist activity, was evaluated in estrogen receptor positive human breast cancer cells (MCF-7) in culture. The compounds were evaluated to determine their antiproliferative activity at a concentration of 1 microM at 2, 4 and 6 days of treatment by hemocytometer using the Trypan Blue exclusion method to count viable cells. Estradiol-induced reversibility of the antiproliferative activity of these compounds was also evaluated. The activity of a series of 19 diaryl- and triarylcyclopropyl compounds was examined. Thirteen compounds inhibited the growth of MCF-7 cells while six were inactive. Five of the 13 active compounds produced antiproliferative activity which was reversed by 0.1 microM estradiol. Thus, several of these novel cyclopropyl compounds may be useful in the treatment of hormone-dependent breast cancer and other estrogen-dependent tumors. |
| Databáze: | OpenAIRE |
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