Follicular variant of papillary thyroid carcinoma presenting as a toxic nodule by I-123 scintigraphy
| Autor: | Sumina Goel, Srinivas Bommireddipalli, Alberto Paniz-MondolFi, Ernest Gordon DePuey, Ramesh Gadiraju |
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| Rok vydání: | 2010 |
| Předmět: |
Male
endocrine system Pathology medicine.medical_specialty Risk of malignancy Carcinoma Papillary Follicular Scintigraphy Thyroid carcinoma Iodine Radioisotopes Fluorodeoxyglucose F18 Cytology medicine Humans Radiology Nuclear Medicine and imaging Thyroid Neoplasms medicine.diagnostic_test business.industry Thyroid Carcinoma Nodule (medicine) General Medicine Middle Aged Carcinoma Papillary medicine.anatomical_structure Thyroid Cancer Papillary Positron-Emission Tomography medicine.symptom Follicular variant business Tomography X-Ray Computed Follow-Up Studies |
| Zdroj: | Clinical nuclear medicine. 35(10) |
| ISSN: | 1536-0229 |
| Popis: | The risk of malignancy in a "hot" thyroid nodule detected by radioiodine scintigraphy is rare. We report a case of a 63-year-old man with a hyperfunctioning nodule demonstrated by radioiodine scintigraphy and cytology suspicious for follicular variant of papillary thyroid carcinoma (FVPTC). There were no locoregional or distant metastases at initial diagnosis. Histopathologic examination following thyroidectomy confirmed the presence of an encapsulated FVPTC. A year into follow-up, his I-131 whole body scan performed following the withdrawal from exogenous thyroid hormone was negative, whereas his serum thyroglobulin (Tg) levels were intermediate. A subsequent PET/CT scan revealed a small, but stable, metabolically active pretracheal lymph node, which on biopsy was confirmed to be stage III FVPTC. In conclusion, the presence of hyperfunctioning thyroid nodule(s) does not preclude malignancy and, therefore, proper cytohistologic evaluation in such patients may help to exclude a coexistent thyroid carcinoma. Patients treated for localized PTC may benefit from serial PET/CT follow-up in the early detection and management of recurrence or distant metastases. |
| Databáze: | OpenAIRE |
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