Sorcin antibody as a possible predictive factor in conversion from radiologically isolated syndrome to multiple sclerosis: a preliminary study
| Autor: | Arzu Çoban, Deniz Akbaş-Demir, Filiz Çavuş, Burçak Vural, Erdem Tüzün, Elçin Şehitoğlu, Melike Küçükerden, Recai Turkoglu, Arda Örçen, Canan Ulusoy |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Neurology Immunology Gastroenterology Multiple Sclerosis Relapsing-Remitting immune system diseases Internal medicine medicine Humans Pharmacology biology business.industry Multiple sclerosis Calcium-Binding Proteins Autoantibody Syndrome medicine.disease Rheumatology nervous system diseases Predictive factor Relapsing remitting Immunoglobulin G biology.protein Biomarker (medicine) Female Antibody business Biomarkers |
| Zdroj: | Inflammation Research. 63:799-801 |
| ISSN: | 1420-908X 1023-3830 |
| Popis: | To identify an antibody biomarker for prediction of conversion from radiologically isolated syndrome (RIS) to relapsing remitting multiple sclerosis (RRMS).Sera of 13 RIS patients were screened by a protein macroarray derived from human fetal brain cDNA library.Sequencing of a clone with the highest signal intensity revealed sorcin as a potential target autoantigen in RIS patients. ELISA studies showed high-titer sorcin-antibodies in 3 of 4 RIS patients who converted to RRMS in a 5-year follow-up period and 13 of 23 control RRMS patients.The value of sorcin antibody as a predictor of conversion from RIS to RRMS requires to be tested in larger prospective studies. |
| Databáze: | OpenAIRE |
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