Inhibition of azoxymethane-induced colon carcinogenesis in rat by green tea polyphenol fraction
| Autor: | Testsuro Yamane, Yoshitaka Kitao, Toshio Takahashi, Shigemitsu Akachi, Mujo Kim, Katsuya Kuwata, Jyunichi Okuzumi, Masao Inagake, Masaya Tateishi, Nobuyuki Hagiwara |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Polyphenol Cancer Research medicine.medical_specialty Pathology Time Factors GTP' Polymers Azoxymethane Epigallocatechin gallate Body weight Catechin Article chemistry.chemical_compound Phenols Oral administration Internal medicine medicine otorhinolaryngologic diseases Animals Flavonoids Tea business.industry Plant Extracts Body Weight Colon carcinogenesis Green tea Rats Inbred F344 (‐)‐Epigallocatechin gallate Rats Endocrinology Oncology chemistry Colonic Neoplasms business |
| Zdroj: | Japanese Journal of Cancer Research : Gann |
| ISSN: | 0910-5050 |
| Popis: | The effect of green tea polyphenol fraction (GTP) on azoxymethane(AOM)-induced colon carcino-genesis was investigated in male Fischer rate. The rats were given AOM (7.4 mg/kg body weight) s.c. once a week for 10 weeks. A week after the treatment, they were divided into three groups: AOM-control (26 rats), AOM-GTP1 (26 rats) and AOM-GTP2 (25 rats). AOM-GTPl and AOM-GTP2 groups respectively received 0.01 and 0.1% GTP in drinking water from week 11 to 26. AOM-control group received tap water throughout this experiment. Autopsy on week 26 showed that tumor incidence and average numbers of tumors per rat in the AOM-GTPl and AOM-GTP2 groups were significantly lower than those of the AOM-control group: 38.1% and 47.6% versus 77.3%; 0.6 and 0.7 versus 1.5. Thus, it was concluded that GTP inhibited the development of AOM-indnced colon carcinogenesis. The inhibition by GTP did not show significant dose dependence. |
| Databáze: | OpenAIRE |
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