ADP-ribosylation systems in bacteria and viruses
| Autor: | Andrea Hloušek-Kasun, Petra Mikolcevic, Ivan Ahel, Andreja Mikoč |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
ADP-ribosylation
ADP-ribosyl transferase ADP-ribosyl hydrolase PARP PARG Macrodomain Toxin-antitoxin system Biophysics Review Article Computational biology Biology medicine.disease_cause PARP PARG Biochemistry Fight-or-flight response 03 medical and health sciences 0302 clinical medicine Immune system Structural Biology Genetics medicine Epigenetics ComputingMethodologies_COMPUTERGRAPHICS 030304 developmental biology 0303 health sciences Pathogenic bacteria biology.organism_classification Pathogenicity Computer Science Applications 030220 oncology & carcinogenesis Posttranslational modification TP248.13-248.65 Bacteria Biotechnology |
| Zdroj: | Computational and Structural Biotechnology Journal Computational and Structural Biotechnology Journa Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 2366-2383 (2021) |
| ISSN: | 2001-0370 |
| DOI: | 10.1016/j.csbj.2021.04.023 |
| Popis: | Graphical abstract ADP-ribosylation is an ancient posttranslational modification present in all kingdoms of life. The system likely originated in bacteria where it functions in inter- and intra-species conflict, stress response and pathogenicity. It was repeatedly adopted via lateral transfer by eukaryotes, including humans, where it has a pivotal role in epigenetics, DNA-damage repair, apoptosis, and other crucial pathways including the immune response to pathogenic bacteria and viruses. In other words, the same ammunition used by pathogens is adapted by eukaryotes to fight back. While we know quite a lot about the eukaryotic system, expanding rather patchy knowledge on bacterial and viral ADP-ribosylation would give us not only a better understanding of the system as a whole but a fighting advantage in this constant arms race. By writing this review we hope to put into focus the available information and give a perspective on how this system works and can be exploited in the search for therapeutic targets in the future. The relevance of the subject is especially highlighted by the current situation of being amid the world pandemic caused by a virus harbouring and dependent on a representative of such a system. |
| Databáze: | OpenAIRE |
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