Repellents Inhibit P450 Enzymes in Stegomyia (Aedes) aegypti
| Autor: | Graham D. Moores, E. Loza-Reyes, James G. Logan, Elena Stashenko, Gloria Isabel Jaramillo Ramirez |
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| Rok vydání: | 2012 |
| Předmět: |
animal structures
Science Enzyme Metabolism DEET Aedes aegypti Biology Biochemistry Microbiology Mosquitoes Vector Biology law.invention Toxicology chemistry.chemical_compound Aedes law Oils Volatile medicine Animals Cytochrome P-450 Enzyme Inhibitors Potency Pesticides Enzyme Inhibitors Essential oil Enzyme Kinetics Multidisciplinary Olfactory receptor fungi Agriculture Vectors and Hosts Pesticide biology.organism_classification Enzymes Infectious Diseases medicine.anatomical_structure chemistry Insect Repellents Medicine Female Pest Control Rabbits Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 7, Iss 11, p e48698 (2012) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0048698 |
| Popis: | The primary defence against mosquitoes and other disease vectors is often the application of a repellent. Despite their common use, the mechanism(s) underlying the activity of repellents is not fully understood, with even the mode of action of DEET having been reported to be via different mechanisms; e.g. interference with olfactory receptor neurones or actively detected by olfactory receptor neurones on the antennae or maxillary palps. In this study, we discuss a novel mechanism for repellence, one of P450 inhibition. Thirteen essential oil extracts from Colombian plants were assayed for potency as P450 inhibitors, using a kinetic fluorometric assay, and for repellency using a modified World Health Organisation Pesticide Evaluations Scheme (WHOPES) arm-in cage assay with Stegomyia (Aedes) aegypti mosquitoes. Bootstrap analysis on the inhibition analysis revealed a significant correlation between P450-inhibition and repellent activity of the oils. |
| Databáze: | OpenAIRE |
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