Temporal lobe volume changes in people at high risk of schizophrenia with psychotic symptoms
| Autor: | Stephen M. Lawrie, Patrick Miller, Heather C. Whalley, David G.C. Owens, Jonathan J.K. Best, Eve C. Johnstone, Julia N Kestelman, Suheib S. Abukmeil |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Psychosis medicine.medical_specialty Time Factors Hippocampus Audiology Amygdala Temporal lobe Developmental psychology 03 medical and health sciences 0302 clinical medicine Risk Factors medicine Humans 030212 general & internal medicine medicine.diagnostic_test Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging Temporal Lobe 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Psychotic Disorders Schizophrenia Brain size Laterality Female Psychology |
| Zdroj: | The British journal of psychiatry : the journal of mental science. 181 |
| ISSN: | 0007-1250 |
| Popis: | BackgroundMagnetic resonance imaging (MRI) has demonstrated abnormalities of brain structure, particularly of the temporal lobes, in schizophrenia. These are thought to be neurodevelopmental in origin, but when they become evident is unknown.AimsTo determine iftemporal lobe volumes reduce during the development of symptoms of schizophrenia in initially well people at high riskofthis disorder.MethodA group of 66 people who had at least two first— or second-degree relatives with schizophrenia and a control group of 20 healthy people had a structural MRI scan ofthe whole brain which was repeated after approximately 2 years. Regions of interest, specifically the amygdala-hippocampus complex and the temporal lobes, were traced semi-automatically by three masked raters with good inter— and intrarater reliabilityResultsRegional brain volume changes over 2 years did notdiffer between high-risk and healthy participants. Within the high-risk group, the 19 people with psychotic symptoms (12 at first assessment) had a mean reduction of 2163 mm3 intherighttemporal lobe compared with 97 mm3 in the 47 without symptoms (P⩵0.02).ConclusionsOur findings suggest that people at high risk of schizophrenia with psychotic symptoms show reductions in temporal lobe volumes. |
| Databáze: | OpenAIRE |
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