Preliminary Biological Evaluation of Novel 99mTc-Cys-Annexin A5 as a Apoptosis Imaging Agent
| Autor: | Chunxiong Lu, Zi-Chun Hua, Minjin Hu, Cheng Tan, Huixin Yu, Ji Yu, Quanfu Jiang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Biodistribution Annexins 99mTc-labelled Rat model Pharmaceutical Science Apoptosis Article Analytical Chemistry lcsh:QD241-441 Residue (chemistry) Mice lcsh:Organic chemistry Drug Discovery In Situ Nick-End Labeling Animals Tissue Distribution Physical and Theoretical Chemistry Annexin A5 biodistribution Biological evaluation Tomography Emission-Computed Single-Photon apoptosis imaging cys-annexin A5 Chemistry Organic Chemistry Apoptosis imaging Hepatic apoptosis Organotechnetium Compounds Rats Biochemistry Liver Chemistry (miscellaneous) Isotope Labeling Molecular Medicine Radiopharmaceuticals Cysteine |
| Zdroj: | Molecules, Vol 18, Iss 6, Pp 6908-6918 (2013) Molecules Volume 18 Issue 6 Pages 6908-6918 |
| ISSN: | 1420-3049 |
| Popis: | A novel annexin A5 derivative (cys-annexin A5) with a single cysteine residue at its C-terminal has been developed and successfully labeled in high labeling yield with (99m)Tc by a ligand exchange reaction. Like the 1st generation (99m)Tc-HYNIC-annexin A5, the novel (99m)Tc-cys-annexin A5 derivative shows in normal mice mainly renal and, to a lesser extent, hepatobiliary excretion. In rat models of hepatic apoptosis there was 283% increase in hepatic uptake of (99m)Tc-cys-annexin A5 as compared to normal mice. The results indicate that the novel (99m)Tc-cys-annexin A5 is a potential apoptosis imaging agent. |
| Databáze: | OpenAIRE |
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