Case Fatality Rate Related to Microcephaly Congenital Zika Syndrome and Associated Factors: A Nationwide Retrospective Study in Brazil †
| Autor: | Mauricio Lima Barreto, Juliane F. Oliveira, Florisneide Rodrigues Barreto, Wanderson K Oliveira, Giovanny Vinícius Araújo de França, Eduardo Hage Carmo, Qeren Hapuk Rodrigues Ferreira Fernandes, Maria da Conceição Nascimento Costa, Martha Suely Itaparica Carvalho, Moreno S. Rodrigues, Maria Glória Teixeira, Luciana L. Cardim, Rafael V. Veiga, Giovanini E. Coelho, Roberto F. S. Andrade, Enny S. Paixão, Rita de Cássia Oliveira de Carvalho-Sauer, Larissa C. Costa |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male congenital Zika syndrome Microcephaly Pediatrics medicine.medical_specialty Adolescent 030231 tropical medicine Population lcsh:QR1-502 Logistic regression lcsh:Microbiology Article Medical Records risks factors Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors Virology Case fatality rate Late preterm Humans Medicine microcephaly 030212 general & internal medicine Pregnancy Complications Infectious education Retrospective Studies education.field_of_study case fatality rate Zika Virus Infection business.industry Retrospective cohort study Middle Aged medicine.disease Low birth weight Logistic Models Infectious Diseases Female medicine.symptom business Brazil |
| Zdroj: | Viruses Volume 12 Issue 11 Viruses, Vol 12, Iss 1228, p 1228 (2020) |
| ISSN: | 1999-4915 |
| Popis: | Background: The clinical manifestations of microcephaly/congenital Zika syndrome (microcephaly/CZS) have harmful consequences on the child&rsquo s health, increasing vulnerability to childhood morbidity and mortality. This study analyzes the case fatality rate and child&ndash maternal characteristics of cases and deaths related to microcephaly/CZS in Brazil, 2015&ndash 2017. Methods: Population-based study developed by linkage of three information systems. We estimate frequencies of cases, deaths, case fatality rate related to microcephaly/CZS according to child and maternal characteristics and causes of death. Multivariate logistic regression models were applied. Results: The microcephaly/CZS case fatality rate was 10% (95% CI 9.2&ndash 10.7). Death related to microcephaly/CZS was associated to moderate (OR = 2.15 95% CI 1.63&ndash 2.83), and very low birth weight (OR = 3.77 95% CI 2.20&ndash 6.46) late preterm births (OR = 1.65 95% CI 1.21&ndash 2.23), Apgar < 7 at 1st (OR = 5.98 95% CI 4.46&ndash 8.02) and 5th minutes (OR = 4.13 95% CI 2.78&ndash 6.13), among others. Conclusions: A high microcephaly/CZS case fatality rate and important factors associated with deaths related to this syndrome were observed. These results can alert health teams to these problems and increase awareness about the factors that may be associated with worse outcomes. |
| Databáze: | OpenAIRE |
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