Hepatic blood flow and energy metabolism during hypotension induced by prostaglandin E1 and nicardipine in rabbits: an in vivo magnetic resonance spectroscopic study
| Autor: | Toshiyuki Arai, Kouichi Kito, Toshiro Inubushi, Kenjiro Mori, Shigehiro Morikawa |
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| Rok vydání: | 1993 |
| Předmět: |
In vivo magnetic resonance spectroscopy
Male medicine.medical_specialty Magnetic Resonance Spectroscopy Nicardipine Hemodynamics Blood Pressure Phosphates chemistry.chemical_compound Adenosine Triphosphate In vivo Internal medicine Medicine Animals Alprostadil Prostaglandin E1 business.industry Metabolism Blood flow Anesthesiology and Pain Medicine Endocrinology Blood pressure chemistry Liver lipids (amino acids peptides and proteins) Rabbits Hypotension business Energy Metabolism medicine.drug Liver Circulation |
| Zdroj: | Anesthesia and analgesia. 77(3) |
| ISSN: | 0003-2999 |
| Popis: | Hepatic blood flow (HBF) and energy metabolism during moderate hypotension induced by prostaglandin E1 (PGE1) and nicardipine were studied by in vivo magnetic resonance spectroscopy. HBF was determined by the deuterated water clearance method by using deuterium magnetic resonance spectroscopy, and energy metabolism was estimated from the changes in the levels of adenosine triphosphate and inorganic phosphate by using phosphorus (31P) magnetic resonance spectroscopy. Mean arterial blood pressure was intentionally reduced to 60% of control with PGE1 (n = 5) or nicardipine (n = 5). The HBF decreased by 38% and by 50% during the hypotension induced by PGE1 and nicardipine, respectively. The level of adenosine triphosphate decreased by 12% and that of inorganic phosphate increased by 80% during nicardipine-induced hypotension, whereas the corresponding levels showed no remarkable changes during PGE1-induced hypotension. After the cessation of drug administration, mean arterial blood pressure and HBF recovered to the control levels in the PGE1 group, but not completely in the nicardipine group. In the latter group, the level of inorganic phosphate did not recover either. These results indicate that during hypotension induced with PGE1 hepatic circulation and metabolism are conserved to a greater extent than during hypotension induced with nicardipine. |
| Databáze: | OpenAIRE |
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