Blood coagulation and fibrinolysis in patients with Cushing's syndrome: increased plasminogen activator inhibitor-1, decreased tissue factor pathway inhibitor, and unchanged thrombin-activatable fibrinolysis inhibitor levels
| Autor: | Mustafa Kocak, Cihangir Erem, Irfan Nuhoglu, Osman Üçüncü, Mustafa Yilmaz, Adem Demirel, H. Önder Ersöz |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Carboxypeptidase B2 Endocrinology Diabetes and Metabolism medicine.medical_treatment Lipoproteins Fibrinogen chemistry.chemical_compound Endocrinology Tissue factor pathway inhibitor Von Willebrand factor Internal medicine Fibrinolysis Plasminogen Activator Inhibitor 1 medicine Humans Blood Coagulation Cushing Syndrome Prothrombin time medicine.diagnostic_test biology business.industry Antithrombin Middle Aged chemistry Plasminogen activator inhibitor-1 biology.protein Female business medicine.drug Partial thromboplastin time |
| Zdroj: | Journal of endocrinological investigation. 32(2) |
| ISSN: | 1720-8386 |
| Popis: | Background and objectives: Cushing’s syndrome (CS) is associated with an increased cardiovascular mortality and morbidity. Chronic endogenous and exogenous hypercortisolism frequently induce a hypercoagulable and thrombotic condition. Little is known about hemostatic features of patients with CS. To our knowledge, plasma tissue factor pathway inhibitor (TFPI) and thrombin-activatable fibrinolysis inhibitor (TAFI) levels in these patients have not been investigated. Therefore, the main purpose of this study was to evaluate the markers of endogenous coagulation/fibrinolysis, including TFPI and TAFI, and to investigate the relationships between cortisol and these hemostatic parameters and serum lipid profile in patients with CS. Design and methods: Twenty-four patients with CS and 24 age-matched healthy controls were included in the study. Prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, factors V, VII, VIII, IX, and X activities, von Willebrand factor (vWF), antithrombin III (AT III), protein C, protein S, tissue plasminogen activator (t-PA), tissue plasminogen activator inhibitor-1 (PAI-1), TFPI and TAFI, as well as common lipid variables, were measured. The relationships between serum cortisol and these hemostatic parameters were examined. Results: Compared with the control subjects, platelet count, PT, fibrinogen, AT-III and PAI-1 were significantly increased in patients with CS (p |
| Databáze: | OpenAIRE |
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