Gadolinium Chelate Safety in Pregnancy: Barely Detectable Gadolinium Levels in the Juvenile Nonhuman Primate after in Utero Exposure
| Autor: | Antonio E. Frias, Karen Y. Oh, Christina Ann Miller, Victoria H. J. Roberts, Elinor L. Sullivan, Joao Prola-Netto, Mark Woods |
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| Rok vydání: | 2018 |
| Předmět: |
Pathology
medicine.medical_specialty Gadolinium Contrast Media chemistry.chemical_element Physiology Macaque 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Heterocyclic Compounds Pregnancy biology.animal Organometallic Compounds medicine Animals Tissue Distribution Radiology Nuclear Medicine and imaging Original Research Fetus Gadolinium-Chelate 030219 obstetrics & reproductive medicine biology Gadoteridol business.industry Transplacental Amniotic Fluid medicine.disease Macaca mulatta Magnetic Resonance Imaging chemistry Maternal Exposure In utero Female business medicine.drug |
| Zdroj: | Radiology. 286:122-128 |
| ISSN: | 1527-1315 0033-8419 |
| Popis: | Purpose To determine whether gadolinium remains in juvenile nonhuman primate tissue after maternal exposure to intravenous gadoteridol during pregnancy. Materials and Methods Gravid rhesus macaques and their offspring (n = 10) were maintained, as approved by the institutional animal care and utilization committee. They were prospectively studied as part of a pre-existing ongoing research protocol to evaluate the effects of maternal malnutrition on placental and fetal development. On gestational days 85 and 135, they underwent placental magnetic resonance imaging after intravenous gadoteridol administration. Amniocentesis was performed on day 135 prior to administration of the second dose of gadoteridol. After delivery, the offspring were followed for 7 months. Tissue samples from eight different organs and from blood were harvested from each juvenile macaque. Gadolinium levels were measured by using inductively coupled plasma mass spectrometry. Results Gadolinium concentration in the amniotic fluid was 0.028 × 10 |
| Databáze: | OpenAIRE |
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