Mitochondrial membrane transporters and metabolic switch in heart failure

Autor: Vikas Kumar, T. R. Santhosh Kumar, C C Kartha
Rok vydání: 2018
Předmět:
Iron
Cardiomegaly
ATP-binding cassette transporter
030204 cardiovascular system & hematology
Mitochondrion
medicine.disease_cause
Mitochondrial Dynamics
Mitochondrial Membrane Transport Proteins
Mitochondria
Heart
03 medical and health sciences
0302 clinical medicine
Animals
Homeostasis
Humans
Medicine
Myocytes
Cardiac
030212 general & internal medicine
Inner mitochondrial membrane
Heart Failure
chemistry.chemical_classification
Reactive oxygen species
Organelle Biogenesis
ATP synthase
biology
business.industry
Mitochondrial Proton-Translocating ATPases
Rats
Cell biology
Oxidative Stress
Ion homeostasis
Electron Transport Chain Complex Proteins
chemistry
Mitochondrial biogenesis
Models
Animal
biology.protein
ATP-Binding Cassette Transporters
Reactive Oxygen Species
Cardiology and Cardiovascular Medicine
business
Oxidative stress
Zdroj: Heart Failure Reviews. 24:255-267
ISSN: 1573-7322
1382-4147
DOI: 10.1007/s10741-018-9756-2
Popis: Mitochondrial dysfunction is widely recognized as a major factor for the progression of cardiac failure. Mitochondrial uptake of metabolic substrates and their utilization for ATP synthesis, electron transport chain activity, reactive oxygen species levels, ion homeostasis, mitochondrial biogenesis, and dynamics as well as levels of reactive oxygen species in the mitochondria are key factors which regulate mitochondrial function in the normal heart. Alterations in these functions contribute to adverse outcomes in heart failure. Iron imbalance and oxidative stress are also major factors for the evolution of cardiac hypertrophy, heart failure, and aging-associated pathological changes in the heart. Mitochondrial ATP-binding cassette (ABC) transporters have a key role in regulating iron metabolism and maintenance of redox status in cells. Deficiency of mitochondrial ABC transporters is associated with an impaired mitochondrial electron transport chain complex activity, iron overload, and increased levels of reactive oxygen species, all of which can result in mitochondrial dysfunction. In this review, we discuss the role of mitochondrial ABC transporters in mitochondrial metabolism and metabolic switch, alterations in the functioning of ABC transporters in heart failure, and mitochondrial ABC transporters as possible targets for therapeutic intervention in cardiac failure.
Databáze: OpenAIRE
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