Retromer dependent changes in cellular homeostasis and Parkinson's disease
| Autor: | Zebin Li, Zhe Yang, Rohan D. Teasdale |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
cell homeostasis
Cell Homeostasis & Autophagy Parkinson's disease Retromer Endosome Cellular homeostasis Endosomes Disease Biology sorting nexin Biochemistry Molecular Bases of Health & Disease Organelles & Localization Parkinsons disease medicine Homeostasis Humans Review Articles Molecular Biology Disease progression Parkinson Disease medicine.disease Cell biology Retromer complex Protein Transport Sorting nexin Cell Migration Adhesion & Morphology protein trafficking retromer Neuroscience |
| Zdroj: | Essays in Biochemistry |
| ISSN: | 1744-1358 0071-1365 |
| DOI: | 10.1042/ebc20210023 |
| Popis: | To date, mechanistic treatments targeting the initial cause of Parkinson's disease (PD) are limited due to the underlying biological cause(s) been unclear. Endosomes and their associated cellular homeostasis processes have emerged to have a significant role in the pathophysiology associated with PD. Several variants within retromer complex have been identified and characterised within familial PD patients. The retromer complex represents a key sorting platform within the endosomal system that regulates cargo sorting that maintains cellular homeostasis. In this review, we summarise the current understandings of how PD-associated retromer variants disrupt cellular trafficking and how the retromer complex can interact with other PD-associated genes to contribute to the disease progression. |
| Databáze: | OpenAIRE |
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