Reduction of Submissive Behavior in Rats: A Test for Antidepressant Drug Activity
| Autor: | Ewa Malatynska, Richard J. Knapp, Rachel Goldenberg, Paula Zamecki, Arif Haque, Glenda Crites, Lucy Shuck, Nancy L. Schindler |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Imipramine Anxiolytic Rats Sprague-Dawley Internal medicine Desipramine medicine Animals Pharmacology Fluoxetine Behavior Animal Depression Significant difference General Medicine Antidepressive Agents Rats Drug activity Endocrinology Models Animal Antidepressant Female Psychology Diazepam Locomotion medicine.drug Clinical psychology |
| Zdroj: | Pharmacology. 64:8-17 |
| ISSN: | 1423-0313 0031-7012 |
| DOI: | 10.1159/000056145 |
| Popis: | Randomly paired rats were food deprived overnight and placed in an apparatus compelling them to compete for a food reward. About half of these pairs developed a dominant-submissive relationship measured as a significant difference in time spent on the feeder by each rat. This relationship developed over a 2-week period and remained stable for at least the next 5 weeks. Treatment of the submissive subjects, for at least 2 weeks, with imipramine, desipramine, or fluoxetine (10 mg/kg) significantly reduced submissive behavior. The effect faded after cessation of treatment with desipramine. Fluoxetine was further tested at 2.5- and 5-mg/kg doses and showed a dose-dependent reduction of submissive behavior. Treatment of submissive rats with the anxiolytic diazepam (1 mg/kg) was ineffective. The prevalence of dominant-submissive relationships and the effect of desipramine and imipramine on submissive behavior were gender independent. The predictive, face, and construct validity of the behavioral test is discussed. |
| Databáze: | OpenAIRE |
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