Weight Loss and the Renin-Angiotensin-Aldosterone System
| Autor: | Michael Bader, K. Gorzelniak, Jürgen Janke, Stefan Engeli, Petra Schling, Jana Böhnke, Friedrich C. Luft, Arya M. Sharma |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
medicine.medical_specialty
Ambulatory blood pressure medicine.drug_class Angiotensinogen Adipose tissue Blood Pressure Peptidyl-Dipeptidase A Renin-Angiotensin System chemistry.chemical_compound Weight loss Internal medicine Renin Weight Loss Renin–angiotensin system Internal Medicine medicine Humans Obesity Aldosterone business.industry Blood Pressure Monitoring Ambulatory Middle Aged Angiotensin II Cross-Sectional Studies Blood pressure Endocrinology ddc: 610 Adipose Tissue chemistry Mineralocorticoid Case-Control Studies Female medicine.symptom business |
| Zdroj: | Hypertonie 2004; 28. Wissenschaftlicher Kongress der Deutschen Hochdruckliga; 20041124-20041127; Hannover; DOC04hochP29 /20050810/ |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.0000154361.47683.d3 |
| Popis: | The renin-angiotensin-aldosterone system has been causally implicated in obesity-associated hypertension. We studied the influence of obesity and weight reduction on the circulating and adipose tissue renin-angiotensin-aldosterone system in menopausal women. Blood samples were analyzed for angiotensinogen, renin, aldosterone, angiotensin-converting enzyme activity, and angiotensin II. In adipose tissue biopsy samples, we analyzed angiotensinogen, renin, renin-receptor, angiotensin-converting enzyme, and angiotensin II type-1 receptor gene expression. Obese women (n=19) had higher circulating angiotensinogen, renin, aldosterone, and angiotensin-converting enzyme than lean women (n=19), and lower angiotensinogen gene expression in adipose tissue. Seventeen women successfully participated in a weight reduction protocol over 13 weeks to reduce daily caloric intake by 600 kcal. Body weight was reduced by −5%, as were angiotensinogen levels by −27%, renin by −43%, aldosterone by −31%, angiotensin-converting enzyme activity by −12%, and angiotensinogen expression by −20% in adipose tissue (all P r =0.74; P |
| Databáze: | OpenAIRE |
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