Levels of oxidative damage and proinflammatory cytokines are enhanced in patients with active vitiligo

Autor:	Richeek Pradhan, Mitali Chatterjee, Debolina Mondal, Arghyaprasun Ghosh, Ayan K. Pati, Sritama De Sarkar, Ayan Pradhan, Suparna Chatterjee, Sneha Mitra, Sumit Sen
Rok vydání:	2017
Předmět:	Adult Male 0301 basic medicine DNA damage Protein Carbonylation Vitiligo Oxidative phosphorylation medicine.disease_cause Biochemistry Proinflammatory cytokine Lipid peroxidation 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans chemistry.chemical_classification Reactive oxygen species integumentary system Chemistry General Medicine medicine.disease Oxidative Stress Cross-Sectional Studies 030104 developmental biology Immunology Cytokines Female Oxidative stress
Zdroj:	Free Radical Research. 51:986-994
ISSN:	1029-2470 1071-5762
Popis:	Vitiligo is an autoimmune depigmenting skin disease characterised by loss of melanocytes wherein oxidative stress is proposed to be the initial triggering factor with subsequent immune dysregulation. This study aimed to evaluate the relationship, if any, between the generation of reactive oxygen species (ROS), markers of oxidative damage and circulating cytokines in patients with active vitiligo. The generation of ROS in erythrocytes and neutrophils was significantly higher in patients with active vitiligo than healthy controls. Alongside, markers of oxidative stress-mediated damage namely lipid peroxidation, DNA damage and protein carbonylation were evaluated. Patients with active vitiligo demonstrated increased lipid and DNA damage but minimal protein damage. There was a significant decline in the free radical scavenging capacity of active vitiligo cases. A positive correlation existed between baseline levels of ROS and lipid peroxidation as also DNA damage. Patients with active vitiligo demonstrated an increase in several proinflammatory (IL-6, TNF-α, IL-1β, IFN-γ and IL-8) and some anti-inflammatory/immunoregulatory (IL-5 and IL-10) cytokines. Importantly, the levels of IFN-γ and IL-10 consistently correlated with the generation of ROS, markers of damage and their free radical scavenging capacity. Taken together, patients with active vitiligo demonstrated an enhanced generation of ROS in erythrocytes and neutrophils which mediated lipid peroxidation, DNA damage and coupled with a decline in their antioxidant capacity created a pro-oxidant milieu that favoured tissue damage and potential generation of neoantigens, accounting for disease progression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019f6968f1698d2693cc8df1cc7d5d96 https://doi.org/10.1080/10715762.2017.1402303 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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