Predominance of G9P[8] Rotavirus Strains throughout France, 2014-2017
| Autor: | Jérôme Kaplon, A. Schnuriger, N. Grangier, A. Beby-Defaux, Vincent Foulongne, Mouna Lazrek, N. Prieur, Jérôme Guinard, Astrid Vabret, Sophie Alain, Y. Mekki, Sylvie Pillet, Véronique Avettand-Fenoel, A. Minoui-Tran, A. de Rougemont, Pierre Pothier, N. Wilhelm, Gisèle Lagathu |
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| Přispěvatelé: | Procédés Alimentaires et Microbiologiques [Dijon] (PAM), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Centre National de Référence des virus entériques [CHU de Dijon] (CNR virus entériques), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), French Rotavirus Network (French RotaNet), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Hôpital de la Cavale Blanche - CHRU Brest (CHU - BREST ), Department of Human and Molecular Virology, Georges Clémenceau Universitary Hospital, Centre hospitalier de Cahors, Centre Hospitalier de Charleville-Mezières, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de Bactériologie, Virologie, Hygiène [CHU Limoges], CHU Limoges, Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques (RESINFIT), CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Laboratoire de Virologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), Laboratoire de microbiologie [CHRU Orléans], Centre Hospitalier Régional d'Orléans (CHRO), Laboratoire de Virologie [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre hospitalier universitaire de Poitiers (CHU Poitiers), CHU Pontchaillou [Rennes], Procédés Alimentaires et Microbiologiques [Dijon] ( PAM ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté ( UBFC ), Centre National de Référence des virus entériques [CHU de Dijon] ( CNR virus entériques ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), French Rotavirus Network ( French RotaNet ), Centre Hospitalier Universitaire de Saint-Etienne ( CHU de Saint-Etienne ), Hôpital de la Cavale Blanche - CHRU Brest ( CHU - BREST ), Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques ( RESINFIT ), CHU Limoges-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut Génomique, Environnement, Immunité, Santé, Thérapeutique ( GEIST ), Université de Limoges ( UNILIM ) -Université de Limoges ( UNILIM ), Centre Hospitalier Lyon Sud [CHU - HCL] ( CHLS ), Hospices Civils de Lyon ( HCL ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Centre Hospitalier Régional d'Orléans ( CHR ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Department of Virology, Assistance publique - Hôpitaux de Paris (AP-HP), CHU de Poitiers, Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université Bourgogne Franche-Comté [COMUE] ( UBFC ), CHU Necker - Enfants Malades [AP-HP]-Assistance publique - Hôpitaux de Paris (AP-HP), Centre hospitalier universitaire de Poitiers ( CHU Poitiers ) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Rotavirus 0301 basic medicine Microbiology (medical) Genotype viruses 030106 microbiology Population Rotavirus Infections Biology medicine.disease_cause [ SDV.MP.VIR ] Life Sciences [q-bio]/Microbiology and Parasitology/Virology Group A Evolution Molecular 03 medical and health sciences 0302 clinical medicine fluids and secretions [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases medicine Humans Outer capsid Prospective Studies 030212 general & internal medicine education Antigens Viral Genotyping Phylogeny education.field_of_study Infant Newborn Infant virus diseases [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology General Medicine Virology 3. Good health [ SDV.MHEP.MI ] Life Sciences [q-bio]/Human health and pathology/Infectious diseases Infectious Diseases Immunization Child Preschool Population Surveillance [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Capsid Proteins Female [ SDV.MHEP.HEG ] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology France |
| Zdroj: | Clinical Microbiology and Infection Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2018, pp.660.e1-660.e4. ⟨10.1016/j.cmi.2017.10.009⟩ Clinical Microbiology and Infection, Wiley, 2017, 〈10.1016/j.cmi.2017.10.009〉 Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2018, 〈10.1016/j.cmi.2017.10.009〉 |
| ISSN: | 1198-743X 1469-0691 |
| DOI: | 10.1016/j.cmi.2017.10.009⟩ |
| Popis: | International audience; OBJECTIVES: Group A rotavirus is a major cause of acute gastroenteritis in young children worldwide. A prospective surveillance network has been set up in France to investigate rotavirus infections and to detect the emergence of potentially epidemic strains.METHODS: From 2014 to 2017, rotavirus-positive stool samples were collected from 2394 children under 5 years old attending the paediatric emergency units of 13 large hospitals. Rotaviruses were genotyped by RT-PCR with regard to their outer capsid proteins VP4 and VP7.RESULTS: Genotyping of 2421 rotaviruses showed that after a marked increase in G9P[8] (32.1%) during the 2014-2015 season, G9P[8] became the predominant genotype during the 2015-2016 and 2016-2017 seasons with detection rates of 64.1% and 77.3%, respectively, whilst G1P[8] were detected at low rates of 16.8% and 6.6%, respectively. Phylogenetic analysis of the partial rotavirus VP7 and VP4 coding genes revealed that all these G9P[8] strains belonged to the lineage III and the P[8]-3 lineage, respectively, and shared the same genetic background (G9-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-H1) as did most of previously detected G9P[8] strains and particularly the emerging G9P[8] strains from the 2004-2005 season in France.CONCLUSIONS: G9P[8] rotaviruses have become the predominant circulating genotype for the first time since their emergence a decade ago. In the absence of rotavirus immunisation programmes in France, our data give an insight into the natural fluctuation of rotavirus genotypes in a non-vaccinated population and provide a base line for a better interpretation of data in European countries with routine rotavirus vaccination. |
| Databáze: | OpenAIRE |
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