Evaluation of radiation treatment volumes for unknown primaries of the head and neck in the era of FDG PET

Autor: S.S. Hahn, A. Platek, Anurag K. Singh, Mary E. Platek, Vishal Gupta, Michael A. LaCombe, Mark K. Farrugia, Wesley L. Hicks, Austin J. Iovoli, Hassan Arshad, Michael Mix, Varun K. Chowdhry, Kimberly E. Wooten, Luke Degraaf, Jeffrey A. Bogart
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Multivariate analysis
medicine.medical_treatment
Cancer Treatment
Diagnostic Radiology
0302 clinical medicine
Medicine and Health Sciences
Tomography
Aged
80 and over
Multidisciplinary
Radiology and Imaging
Squamous Cell Carcinomas
Middle Aged
Primary tumor
Head and Neck Tumors
Treatment Outcome
Oncology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
Medicine
Female
Radiology
Anatomy
Research Article
Clinical Oncology
Adult
medicine.medical_specialty
Imaging Techniques
Science
Radiation Therapy
Neuroimaging
Research and Analysis Methods
Radiation Dosage
Carcinomas
03 medical and health sciences
Head and Neck Squamous Cell Carcinoma
Diagnostic Medicine
Fluorodeoxyglucose F18
medicine
Carcinoma
Humans
Survival analysis
Aged
business.industry
Cancer
Biology and Life Sciences
Cancers and Neoplasms
medicine.disease
Head and neck squamous-cell carcinoma
Survival Analysis
Radiation therapy
030104 developmental biology
Head and Neck Cancers
Positron-Emission Tomography
Mann–Whitney U test
Neoplasms
Unknown Primary
Clinical Medicine
business
Head
Neck
Positron Emission Tomography
Neuroscience
Zdroj: PLoS ONE, Vol 15, Iss 4, p e0231042 (2020)
PLoS ONE
ISSN: 1932-6203
Popis: Objectives Positron-emission tomography (PET) has improved identification of the primary tumor as well as occult nodal burden in cancer of the head and neck. Nevertheless, there are still patients where the primary tumor cannot be located. In these situations, the standard of care is comprehensive head and neck radiation therapy however it is unclear whether this is necessary. This study examines the effects of radiation treatment volume on outcomes among using data from two cancer centers in unknown primary carcinoma of the head and neck. Methods Patients received unilateral (n = 34), or bilateral radiation (n = 28). Patient factors such as age, gender, smoking history, and patterns of failure were compared using Mann Whitney U and Chi Square. Overall survival (OS) and disease free survival (DFS) trends were estimated using Kaplan-Meier survival curves. Effect of treatment volume on survival was examined using multivariate cox proportional hazard regression model. Results No significant differences were observed in the frequency of local (p = 0.32), regional (p = 0.50), or distant (p = 0.76) failures between unilateral and bilateral radiation therapy. By Kaplan-Meier estimates, OS (3-year OS bilateral = 71.67%, unilateral = 77.90%, p = 0.50) and DFS (3-year DFS bilateral = 77.92%, unilateral = 69.43%, p = 0.63) were similar between the two treatment approaches. Lastly, multivariate analysis did not demonstrate any significant differences in outcome by treatment volumes (OS: HR = 0.74, 95% CI: 0.31, 1.81, p = 0.51; DFS: HR: 0.68, 95% CI: 0.24, 1.93, p = 0.47). Conclusions Unilateral radiation therapy compared with bilateral produced similar survival.
Databáze: OpenAIRE
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