Uterotonic plants and their bioactive constituents
| Autor: | Margaret O'Brien, Christian W. Gruber |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
myometrial smooth muscle
Pharmaceutical Science Uterotonic Bioinformatics Analytical Chemistry labour Uterine Contraction 0302 clinical medicine Pregnancy Drug Discovery Screening procedures 2. Zero hunger 0303 health sciences protein-kinase-c 030219 obstetrics & reproductive medicine plants Preterm labour gynaecology 3. Good health Tocolytic Agents Drug development Myometrium Plant species Molecular Medicine Female cyclotides medicine.medical_specialty Tocolytic agent Biology corticotropin-releasing hormone Article human myometrial cells supercritical-fluid extraction cyclic-cystine-knot 03 medical and health sciences smooth-muscle-cells Obstetric Labor Premature Internal medicine oxytocin medicine Humans 030304 developmental biology Pharmacology Plant Extracts Organic Chemistry medicine.disease women's health Cyclotide Endocrinology Complementary and alternative medicine isolated rat uterus tumor-necrosis-factor medicinal-plants human-fetal membranes Phytotherapy |
| Popis: | Abnormalities in the process of uterine muscle contractility during pregnancy and birth can have major clinical implications, including preterm labour, which is the single largest cause of maternal and prenatal mortality in the Western world and a major contributor to childhood developmental problems. In contrast, induction of labour may be necessary in certain conditions. Currently used interventional therapies to suppress (tocolytic agents) or to induce (uterotonic agents) uterine contractions lack potency and/or selectivity and can have harmful side effects for mother and baby. Nature’s diversity has always been, and still is, one of the biggest resources of therapeutic lead compounds. Many natural products exhibit biological activity against unrelated targets, thus providing researchers with starting points for drug development. In this review we will provide an overview of uterine muscle physiology, describe currently available biological screening procedures for testing of uterotonic plant compounds and will summarise traditionally-used uterotonic plants, their active components and their mechanisms, primarily focusing on uterotonic active circular plant peptides called cyclotides. Finally we will comment on the discovery of novel cyclotide-producing plant species and the possibility for the development of novel plant-derived uterotonic and tocolytic drugs. |
| Databáze: | OpenAIRE |
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