| Autor: |
Samuel Toluwani Akinyele, Christianah Abimbola Elusiyan, Nusrat Omotayo Omisore, Clement Oladapo Adewunmi |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of Ethnopharmacology. 296:115359 |
| ISSN: |
0378-8741 |
| Popis: |
Locally, among the Yoruba speaking people of South Western, Nigeria, the bulb of Crinum jagus (CJ), known as "ogede odo" is used to treat malaria and as an anthelmintic among other uses.Study aimed at identifying the purified active fractions and constituents of this fraction in an antiplasmodial activity-guided process.Antiplasmodial activity-guided fractionation of the bulb and leaf extracts of CJ was investigated against chloroquine-sensitive (NK 65) Plasmodium berghei using 4-day suppressive and prophylactic methods. Molluscicidal activity of the extracts was assayed on adult Biomphalaria glabrata molluscs following WHO test protocols. Fractionation and purification of the active bulb extract was achieved using various chromatographic and spectroscopic techniques to isolate its constituents. Isolated compounds were identified using different spectroscopic methods.Both extracts had oral median lethal dose (LDThe leaf and bulb extracts of Crinum jagus displayed low molluscicidal and moderate antimalarial activities. Lycorine and crinamine were identified from the antiplasmodial alkaloidal active fraction of the bulb. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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