Synthetic Cannabinoid-Associated Coagulopathy: Case Report
| Autor: | Andrew F. Angelino, Colleen Zorn, Vanessa Ruales, Weronika Micula-Gondek |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty Vitamin K Synthetic Drugs Poison control 03 medical and health sciences chemistry.chemical_compound Plasma 0302 clinical medicine Arts and Humanities (miscellaneous) Synthetic cannabinoids medicine Coagulopathy Humans International Normalized Ratio Intensive care medicine Adverse effect Applied Psychology Hematuria Cardiotoxicity business.industry Cannabinoids Warfarin Acute kidney injury Anticoagulants 4-Hydroxycoumarins Blood Coagulation Disorders medicine.disease Antifibrinolytic Agents 030227 psychiatry Psychiatry and Mental health chemistry Prothrombin Time Female Partial Thromboplastin Time Uterine Hemorrhage business Drug Contamination Gastrointestinal Hemorrhage Brodifacoum 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Psychosomatics. 60(2) |
| ISSN: | 1545-7206 |
| Popis: | Synthetic cannabinoids (SC) were developed in the 1980s for the use in studies on the human endo-cannabinoid receptor system. They have since become popular drugs of abuse and have been advertised as natural, safe and promising “legal highs”. The use of SC is increasing worldwide despite documented potential for dependence and harmful effects on health. SC use has been associated with severe adverse events identified through emergency room visits or poison control calls, including seizures, acute kidney injury, cardiotoxicity and deaths. This case report describes a patient with Synthetic Cannabinoid-Associated Coagulopathy related to the use of SC contaminated by “superwarfarin” brodifacoum (BDF), a highly lethal rodenticide. Poisoning with BDF in humans manifest several days after ingestion and results in severe bleeding diathesis that may occur even many months from exposure and may be fatale if untreated as BDF is 100-fold more potent than warfarin. SC use presents a major public health concern and the medical community ought to be aware of the different potential contaminants combined with these synthetic substances, as well as the extent and severity of their clinical effects, which can be unpredictable. |
| Databáze: | OpenAIRE |
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