Frequency-specific oscillations synchronization in primary angle-closure glaucoma
| Autor: | Chen Yu, Jin-Min Zuo, Fei Jiang, Xin Huang, Yin-Quan Ye, Xianjun Zeng |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Radiological and Ultrasound Technology business.industry Brain Glaucoma General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Primary angle-closure glaucoma 03 medical and health sciences 0302 clinical medicine Neuroimaging Ophthalmology Synchronization (computer science) 030221 ophthalmology & optometry medicine Humans Female Radiology Nuclear Medicine and imaging Glaucoma Angle-Closure business 030217 neurology & neurosurgery |
| Zdroj: | Acta Radiologica. 61:537-548 |
| ISSN: | 1600-0455 0284-1851 |
| Popis: | Background Previous neuroimaging studies demonstrated that patients with primary angle-closure glaucoma were accompanied by abnormal neuronal activity. Purpose To investigate frequency-dependent local oscillations synchronization in primary angle-closure glaucoma using the regional homogeneity method. Material and Methods In total, 37 individuals with primary angle-closure glaucoma (20 men, 17 women) and 37 normal-sighted controls (20 men, 17 women) closely matched in age, sex, and education underwent resting-state MRI scans. We compared the different regional homogeneity values in full band (0.01–0.08 Hz) and two different frequency bands (slow-4: 0.027–0.073 Hz and slow-5: 0.010–0.027 Hz) between two groups. Results Compared to the normal-sighted group, the primary angle-closure glaucoma group showed decreased regional homogeneity values in the left calcarine and left postcentral in full band. The primary angle-closure glaucoma group showed increased regional homogeneity values in the bilateral superior medial frontal lobe in the slow-4 band. The primary angle-closure glaucoma group exhibited decreased regional homogeneity values in the right calcarine in the slow-5 band. Specifically, we found that the regional homogeneity values in the right superior frontal lobe were greater in the slow-4 than in the slow-5 band, whereas regional homogeneity in the left calcarine, right pallidum, left inferior occipital gyrus, left superior occipital gyrus, left postcentral/angular gyrus, left paracentral lobule, left superior parietal gyrus, and right precuneus gyrus were greater in the slow-5 than in the slow-4 band. Conclusion Primary angle-closure glaucoma groups showed abnormal regional homogeneity in visual network (calcarine) and default mode network (superior medial frontal lobe) at two frequency bands. Moreover, the regional homogeneity signals in slow-5 band showed closely related to the severity of individuals with primary angle-closure glaucoma. |
| Databáze: | OpenAIRE |
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