In Vitro and in Vivo Studies on Biomedical Magnesium Low-Alloying with Elements Gadolinium and Zinc for Orthopedic Implant Applications
| Autor: | Nan Li, Zhenpeng Guan, Wenting Li, Yuhui Kou, Dong Bian, Hong Cai, Baoguo Jiang, Peng Xiu, Yufeng Zheng, Rongshi Chen, Yang Liu, Jiuxu Deng, Yu Zhang, Xiao Chu |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
Biocompatibility Gadolinium Alloy chemistry.chemical_element Biocompatible Materials 02 engineering and technology Zinc engineering.material 010402 general chemistry 01 natural sciences Rats Sprague-Dawley In vivo Materials Testing Alloys Animals General Materials Science Magnesium X-Ray Microtomography 021001 nanoscience & nanotechnology Microstructure 0104 chemical sciences Mischmetal Rats Corrosion chemistry engineering 0210 nano-technology Nuclear chemistry |
| Zdroj: | ACS applied materialsinterfaces. 10(5) |
| ISSN: | 1944-8252 |
| Popis: | Ternary magnesium alloys with low combined addition of elements gadolinium and zinc were developed in the present work, with their microstructures, mechanical properties, in vitro degradation behaviors, and cytotoxicity being systematically studied. Furthermore, the Mg-1.8Zn-0.2Gd alloy, with the best in vitro performance, was implanted into Sprague Dawley rats to examine its in vivo degradation performance for up to 6 months. It was found that Mg-1.8Zn-0.2Gd, composed of a single α-Mg phase, owned excellent strength and toughness that were comparable to the CE marked MAGNEZIX, the mischmetal added Mg alloy. Owing to the uniform single-phased microstructure, the degradation rate of this alloy was around 0.12 mm/y measured by electrochemical testing, which was comparable to high purity magnesium. Moreover, the Mg-1.8Zn-0.2Gd alloy exhibited no cytotoxicity to L929, MG63, and VSMC cells. In vivo degradation characterized by micro-computed tomography revealed that the Mg-1.8Zn-0.2Gd implant could maintain structural integrity in the first 2 months, and serious degradation could be observed after 6 months. A remarkable 100% survival rate of experimental animals was observed with no negative effects on bone tissues. The implant and the surrounding bone were well integrated within 2 months, implying good biocompatibility and osteoconductivity of the experimental alloy. On the basis of the above findings, the feasibility of Mg-Zn-Gd alloys for use as orthopedic implants was systematically discussed. This study provides a new strategy for development of high-performance Mg-rare earth (RE)-based alloys with superior mechanical properties and corrosion resistance while effectively avoiding the possible standing toxic effect of RE elements. |
| Databáze: | OpenAIRE |
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