Fatty Liver, and Not Visceral Fat, Is More Associated with Liver Fibrosis and Diabetes in Non-Obese Japanese Individuals: A Cross-Sectional Study
| Autor: | Jun Nakamura, Ken Haruma, Takako Sasai, Tomohiro Tanikawa, Katsunori Ishii, Tomoari Kamada, Noriaki Manabe, Hirofumi Kawamoto, Ken Nishino, Noriyo Urata, Miwa Kawanaka, Mitsuhiko Suehiro |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
nonalcoholic fatty liver disease medicine.medical_specialty visceral fat gastroenterology Gastroenterology Article General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Diabetes mellitus Internal medicine insulin resistance Nonalcoholic fatty liver disease Hyperlipidemia medicine lcsh:Science Ecology Evolution Behavior and Systematics fatty liver medicine.diagnostic_test Triglyceride business.industry non-obese Fatty liver Paleontology medicine.disease 030104 developmental biology chemistry lean nonalcoholic fatty liver disease Space and Planetary Science Uric acid 030211 gastroenterology & hepatology lcsh:Q Liver function tests business |
| Zdroj: | Life, Vol 10, Iss 175, p 175 (2020) Life Volume 10 Issue 9 |
| ISSN: | 2075-1729 |
| Popis: | Asians are known to be more likely than Westerners to develop fatty liver and lifestyle-related diseases in spite of their weight. However, the relationship between fat accumulation and lifestyle-related diseases in non-obese Asians is unknown. Therefore, this study aimed to analyze visceral fat and hepatic fat in participants with a normal body mass index (BMI) and examine their characteristics during a medical checkup. This cross-sectional study was conducted on 663 of 1142 patients who underwent abdominal ultrasonography and who had an alcohol intake (converted to ethanol) of < 30 g/day for males and < 20 g/day for females and a BMI of < 25 kg/m2 during a health checkup. Participants were classified into four groups: group A, visceral fat accumulation (VFA) (&minus ) and fatty liver (FL) (&minus ) (n = 549) group B, VFA (+) and FL (&minus ) (n = 32) group C, VFA (&minus ) and FL (+) (n = 58) and group D, VFA (+) and FL (+) (n = 24). The frequencies of lifestyle-related disease complications, liver function tests, and liver fibrosis were evaluated among the four groups. Compared with group A (control), groups B, C, and D had a higher number of males, BMI, abdominal circumference, ALT, AST, &gamma GTP, triglyceride, uric acid, fasting blood sugar levels, and incidence of hyperlipidemia. Groups C and D had higher ALT, HbA1c, cholinesterase, and triglyceride levels, FIB4 index, and the number of patients with diabetes mellitus (DM) than groups A and B however, there was no difference between groups A and B. FL is a risk factor of DM and liver fibrosis in non-obese Japanese individuals however, VFA only is not a risk factor of DM and liver fibrosis. |
| Databáze: | OpenAIRE |
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