The effect of lindane and phenobarbital on microsomal enzyme induction in dogs and miniature swine
| Autor: | Francis L. Earl, Eugene J. Smith, T.M. Farber, E.J. Van Loon |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Swine Miniature swine Toxicology Beagle Mixed Function Oxygenases chemistry.chemical_compound Dogs Species Specificity Internal medicine Demethylase activity medicine Animals Enzyme inducer Pharmacology biology Endocrinology chemistry Biochemistry Enzyme Induction Phenobarbital Microsomes Liver biology.protein Microsome Demethylase Female Lindane Hexachlorocyclohexane medicine.drug |
| Zdroj: | Toxicology and Applied Pharmacology. 37:319-330 |
| ISSN: | 0041-008X |
| Popis: | The enzymic activities of 9000g supernatant fractions obtained from the livers of normal beagle dogs and miniature swine and of dogs and swine treated with lindane and phenobarbital are presented. No significant sex differences in activities were noted in control dogs. Preparations from dogs of both sexes fed lindane at 7.5 and 15.0 mg/kg exhibited a significant loss in codeine demethylase activity while nitroreductase activity was increased twofold. Phenobarbital pretreatment of dogs and swine stimulated all microsomal systems tested. Addition of lindane to the diet of these induced dogs caused a significant and rapid decline in the values after only two feedings. Enzymes induced to a greater extent in dogs by phenobarbital were inhibited to a greater extent by lindane; i.e., as a class, demethylases were affected by both lindane and phenobarbital to a greater extent than aromatic hydroxylases. In contrast, administration of lindane to phenobarbitaltreated swine caused an actual further increase in demethylase activities. A decrease in the induced state was observed in aromatic hydroxylation, azo-reduction, and nitro-reduction reactions, although the activities of these enzymes were still higher than the values from control swine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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