Variation and constraints in hybrid genome formation
| Autor: | Cassandra Nicole Trier, Glenn-Peter Sætre, Tore O. Elgvin, Fabrice Eroukhmanoff, Mark Ravinet, Michael Matschiner, Jo S. Hermansen, Anna Runemark |
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| Přispěvatelé: | University of Zurich, Runemark, Anna |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Gene Flow
0301 basic medicine Candidate gene Introgression Biology 10125 Paleontological Institute and Museum Genome 03 medical and health sciences Genetic algorithm Genetic variation Animals Allele Italian sparrow Sicily Gene Ecology Evolution Behavior and Systematics Genetics Greece Ecology Malta Reproductive isolation biology.organism_classification 030104 developmental biology 1105 Ecology Evolution Behavior and Systematics 560 Fossils & prehistoric life Plumage Evolutionary biology Hybridization Genetic France 2303 Ecology Sparrows |
| DOI: | 10.1101/107508 |
| Popis: | SummaryRecent genomic investigations have revealed hybridization to be an important source of variation, the working material of natural selection1,2. Hybridization can spur adaptive radiations3, transfer adaptive variation across species boundaries4, and generate species with novel niches5. Yet, the limits to viable hybrid genome formation are poorly understood. Here we investigated to what extent hybrid genomes are free to evolve or whether they are restricted to a specific combination of parental alleles by sequencing the genomes of four isolated island populations of the homoploid hybrid Italian sparrowPasser italiae6,7. Based on 61 Italian sparrow genomes from Crete, Corsica, Sicily and Malta, and 10 genomes of each of the parent speciesP. domesticusandP. hispaniolensis,we report that a variety of novel and fully functional hybrid genomic combinations have arisen on the different islands, with differentiation in candidate genes for beak shape and plumage colour. There are limits to successful genome fusion, however, as certain genomic regions are invariably inherited from the same parent species. These regions are overrepresented on the Z-chromosome and harbour candidate incompatibility loci, including DNA-repair and mito-nuclear genes; loci that may drive the general reduction of introgression on sex chromosomes8. Our findings demonstrate that hybridization is a potent process for generating novel variation, but variation is limited by DNA-repair and mito-nuclear genes, which play an important role in reproductive isolation and thus contribute to speciation. |
| Databáze: | OpenAIRE |
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