Dispersed human immunoglobulin κ light-chain genes
| Autor: | Hans-Gunther Bauer, K H Grzeschik, H D Pohlenz, Hans G. Zachau, Bernhard Straubinger, Erika Lötscher |
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| Rok vydání: | 1986 |
| Předmět: |
Genetics
Multidisciplinary Base Sequence Genetic Linkage Pseudogene Chromosomes Human 1-3 Immunoglobulin Variable Region Chromosome Locus (genetics) Biology Immunoglobulin light chain Immunoglobulin kappa-Chains Genes Genetic linkage Chromosomes Human 21-22 and Y Humans Immunoglobulin heavy chain Gene Chromosomes Human 13-15 Kappa |
| Zdroj: | Nature. 320:456-458 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/320456a0 |
| Popis: | The gene segments encoding the constant and variable regions of human immunoglobulin light chains of the kappa type (C kappa, V kappa) have been localized to chromosome 2. The distance between the C kappa and V kappa genes and the number of germline V kappa genes are unknown. As part of our work on the human V kappa locus, we have now mapped two solitary V kappa gene and a cluster of three V kappa genes to chromosomes 1, 15 and 22, respectively. The three genes that have been sequenced are nonprocessed pseudogenes, and the same may be true for the other two genes. This is the first time that V-gene segments have been found outside the C-gene-containing chromosomes. Our finding is relevant to current estimates of the size of the V kappa-gene repertoire. Furthermore, the dispersed gene regions have some unusual characteristics which may help to clarify the mechanism of dispersion. |
| Databáze: | OpenAIRE |
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