Effect of decabrominated diphenyl ether exposure on spatial learning and memory, the expression and phosphorylation of hippocampal glutamate receptor subunits in adult Sprague-Dawley rats
| Autor: | Hao Liyue, He Ting, Zhu Shanshan, Gu Wenwen, Zeng Fancai, Li Xiong, Li Maoting, Li Ya, Yang Zhen, Tang Yan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Protein subunit Spatial Learning Morris water navigation task Gene Expression 010501 environmental sciences Hippocampal formation Toxicology 01 natural sciences Hippocampus Receptors N-Methyl-D-Aspartate Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Sprague dawley rats Halogenated Diphenyl Ethers Animals Receptors AMPA Phosphorylation Maze Learning 0105 earth and related environmental sciences Flame Retardants Spatial Memory Memory Disorders Chemistry Learning Disabilities musculoskeletal neural and ocular physiology Diphenyl ether Glutamate receptor Endocrinology nervous system Spatial learning psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | The Journal of toxicological sciences. 43(11) |
| ISSN: | 1880-3989 |
| Popis: | Previous studies have reported the potential developmental neurobehavioral effects of decabrominated diphenyl ethers (BDE 209) on developing animals, but the effects on adult animals are rare or controversial and the mechanism is not fully understood. In the present study, male adult Sprague-Dawley rats performed poor spatial learning and memory in Morris water maze after exposure to BDE 209 by gavage for 30 days. The expression of hippocampal glutamate receptor subunits NR1, NR2B and GluR1, the phosphorylation of NR2B subunit at Ser1301 (p-NR2B Ser1303) and GluR1 subunit at Ser831 (p-GluR1 Ser831) were all decreased, and the phosphorylation ratio of NR2B revealed an increasing trend after BDE 209 exposure. The present study provided evidence that BDE 209 could induce spatial learning and memory deficits in adult rats, and further explored the potential mechanism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|