Phenol-like group functionalized graphene quantum dots structurally mimicking natural antioxidants for highly efficient acute kidney injury treatment
| Autor: | Huan Wang, Daowei Li, Zhen Liu, Ya Zhou, Xiaogang Qu, Jiao Fang, Jinsong Ren, Dongqin Yu |
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| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species Antioxidant medicine.medical_treatment Acute kidney injury Functionalized graphene General Chemistry Pharmacology medicine.disease urologic and male genital diseases chemistry.chemical_compound Chemistry chemistry Polyphenol Toxicity medicine Phenol Function (biology) |
| Zdroj: | Chemical Science |
| ISSN: | 2041-6520 |
| Popis: | Acute kidney injury (AKI) is a syndrome characterized by rapid loss of renal excretory function with high in-hospital mortality. The excess generation of reactive oxygen species (ROS) in the kidneys during AKI has been considered a major cause of renal failure. Currently available antioxidants for AKI treatment often lack the required antioxidative efficacy or renal accumulation rate. Herein, inspired by the structure of natural phenolic antioxidants, phenol-like group functionalized graphene quantum dots (h-GQDs) with both high ROS scavenging efficacy and renal specificity are constructed for AKI antioxidative therapy. Similar to natural polyphenols, the abundant phenol-like groups on h-GQDs are demonstrated to be the active components exerting antioxidative effects. Further exhaustive mechanistic investigations indicate that the ultrahigh antioxidative activity of h-GQDs originates not solely from the phenol-like groups, but also from the synergy between adjacent phenol-like groups, as well as the removal of unfavorable carbonyl groups on h-GQDs. In AKI mice, h-GQDs can effectively protect the kidneys from oxidative injury with only a one-sixteenth dose of the clinical antioxidant N-acetylcysteine (NAC) and show no evidence of toxicity. The findings of this study will facilitate development of high-performance carbon-based antioxidative platforms via structure–activity relationships for treating AKI and other ROS-related diseases. Phenol-like group functionalized graphene quantum dots that structurally mimic natural antioxidants are constructed as high-efficacy reactive oxygen species scavengers for acute kidney injury antioxidative therapy. |
| Databáze: | OpenAIRE |
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