Current status of MR imaging of juvenile idiopathic arthritis
| Autor: | Tarimobo M. Otobo, Clara Malattia, M. Mazzoni, Margalit Zlotnik, Andrea S. Doria, Mirkamal Tolend, Logi Vidarsson, Jyoti Panwar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Scoring system Arthritis Physical medicine and rehabilitation Rheumatology Outcome Assessment Health Care medicine Humans Magnetic resonance imaging (MRI) skin and connective tissue diseases Child Diffusion weighted MRI Pathological Children Whole body MRI medicine.diagnostic_test business.industry Magnetic resonance imaging Juvenile idiopathic arthritis medicine.disease Mr imaging Magnetic Resonance Imaging Arthritis Juvenile Dynamic contrast-enhanced MRI T2 mapping of cartilage Biomarker (medicine) Growing joints Elastography business Biomarkers Diffusion MRI |
| Popis: | Juvenile idiopathic arthritis (JIA) is the most common chronic arthropathy in the pediatric population. Although the diagnosis is essentially clinical for many affected joints, MR imaging has become an important tool for the assessment of joints that are difficult to evaluate clinically, such as temporomandibular and sacroiliac joints, and for screening of inflammatory changes in the entire body by whole body MRI (WBMRI) assessment. The utilization of MR imaging is challenging in the pediatric population given the need for discrimination between pathological and physiological changes in the growing skeleton. Several multicentric multidisciplinary organizations have made major efforts over the past decades to standardize, quantify, and validate scoring systems to measure joint changes both cross-sectionally and longitudinally according to rigorous methodological standards. In this paper, we (1) discuss current trends for the diagnosis and management of JIA, (2) review challenges for detecting real pathological changes in growing joints, (3) summarize the current status of standardization of MRI protocols for data acquisition and the quantification of joint pathology in JIA by means of scoring systems, and (4) outline novel MR imaging techniques for the evaluation of anatomy and function of joints in JIA. Optimizing the role of MRI as a robust biomarker and outcome measure remains a priority of future research in this field. |
| Databáze: | OpenAIRE |
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