Anesthetics inhibit pressure-induced repetitive impulse generation
| Autor: | T. M. Schneider, E. N. Cohen, J. J. Kendig |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Drug
Physiology media_common.quotation_subject Action Potentials chemistry.chemical_element Alcohol Astacoidea In Vitro Techniques Pharmacology Oxygen chemistry.chemical_compound Physiology (medical) medicine Animals media_common Ethanol Inhalation Chemistry Axons Atmospheric Pressure Phenobarbital High pressure Anesthesia Anesthetic Halothane medicine.drug |
| Zdroj: | Journal of Applied Physiology. 45:747-750 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.1978.45.5.747 |
| Popis: | Repetitive and spontaneous impulse generation appears in nerve axons exposed to high pressure. This phenomenon is a possible basis for high-pressure nervous syndrome (HPNS) or pressure reversal of anesthesia, two examples of an antagonistic interaction between anesthetic drugs and high pressure. In the present study, the interactions between three classes of anesthetic drug (ethyl alcohol, the volatile inhalation agent halothane, and phenobarbital) and repetitive activity were explored. Ethyl alcohol (5% in solution) and halothane (1.3 and 3.4% in oxygen) inhibited pressure-induced repetitive activity. Phenobarbital at 0.25 mM in solution, the maximum concentration obtainable at low temperature, was partially effective. The three drugs produce an unconscious state that is “reversed” at hyperbaric pressure. Halothane and phenobarbital inhibit HPNS, but ethyl alcohol has not been tested for this property. The results thus support a relevance of repetitive activity to HPNS, to pressure reversal of anesthesia, or to both. |
| Databáze: | OpenAIRE |
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