Neuronal localization of CD38 antigen in the human brain
| Autor: | Kazuhiko Ikeda, Mitsunori Yamada, Toshiaki Katada, Maroto Sato, Masashi Mizuguchi, Yoshifumi Ishii, Naruhito Otsuka, Hiroshi Nishina, Shin-ichiro Kon |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Adolescent medicine.drug_class Central nervous system Blotting Western Biology Monoclonal antibody Immunoenzyme Techniques Purkinje Cells Antigen immune system diseases Antigens CD hemic and lymphatic diseases medicine Humans Tissue Distribution ADP-ribosyl Cyclase Molecular Biology N-Glycosyl Hydrolases Aged Neurons Membrane Glycoproteins General Neuroscience Brain hemic and immune systems Human brain Middle Aged Molecular biology ADP-ribosyl Cyclase 1 Antigens Differentiation Blot medicine.anatomical_structure Polyclonal antibodies biology.protein Immunohistochemistry Neurology (clinical) Neuron Developmental Biology |
| Zdroj: | Brain research. 697(1-2) |
| ISSN: | 0006-8993 |
| Popis: | CD38 is a lymphocyte differentiation antigen which is involved in the cyclic ADP-ribose-mediated second messenger system. We provide immunochemical and immunohistochemical evidence for the expression of CD38 in the adult human brain. We used six polyclonal antibodies against synthetic CD38 polypeptides, in addition to four monoclonal antibodies already available. Brain CD38 was detectable by Western blotting after immunoaffinity purification of the brain extracts. Immunoperoxidase staining localized CD38 immunoreactivity to the perikarya and dendrites of many neurons, such as the cerebellar Purkinje cells, implying that CD38 is involved in the signal transduction within the central nervous system neurons. |
| Databáze: | OpenAIRE |
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