Synthesis and application of a series of amphipathic chitosan derivatives and the corresponding magnetic nanoparticle-embedded polymeric micelles
| Autor: | Qingquan Tian, Huimin Tan, Liqiu Chu, Zhipan Feng, Yutong Zhang, Xinqi Zhao, Yu Chen, Xianping Yao, Jueying Yang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Polymers and Plastics
Chemistry Organic Chemistry technology industry and agriculture Nanoparticle 02 engineering and technology Polyethylene glycol 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Reductive amination Combinatorial chemistry 0104 chemical sciences Hydrophobic effect Chitosan chemistry.chemical_compound Drug delivery Amphiphile Materials Chemistry lipids (amino acids peptides and proteins) 0210 nano-technology Drug carrier |
| Zdroj: | Carbohydrate Polymers. 223:114966 |
| ISSN: | 0144-8617 |
| DOI: | 10.1016/j.carbpol.2019.06.005 |
| Popis: | Magnetic nanoparticle-embedded polymeric micelles (MNP-PMs) prepared with amphipathic polymers are an important sustained-release carrier for hydrophobic drugs. The amphipathic chitosan derivatives (ACDs) based stimuli-responsive slow-release carriers have attracted considerable attentions because of the bioactivities and modifiability of chitosan. In the current study, a series of ACDs including alkylated N-(2-hydroxy) propyl-3-trimethyl ammonium chitosan chloride (alkyl-HTCC) and alkylated polyethylene glycol N-(2-hydroxy) propyl-3-trimethyl ammonium chitosan chloride (alkyl-PEG-HTCC) were prepared by the reductive amination of HTCC and PEG-HTCC, and their structures and properties were characterized. Octyl-HTCC/O-Fe3O4 and octyl-PEG-HTCC/O-Fe3O4 MNP-PMs were prepared by the hydrophobic interactions between the corresponding ACDs and oil soluble Fe3O4 magnetic nanoparticles (O-Fe3O4 MNPs), and characterized for the structure, magnetic performance and surface charge state. Their potential application as a drug delivery carrier was investigated upon the embedding efficiency and pH dependent sustained-release performance using the hydrophobic drug, paclitaxel (PTX), as a model drug. Our work has provided a new application strategy of ACDs in the multi-functional drug delivery carrier. |
| Databáze: | OpenAIRE |
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