Markers of oxidative stress after renal transplantation
| Autor: | Blagojevic R, Tatjana Simic, S. Markovic, Zorica Reljic, Lj Djukanović, Visnja Lezaic, Sanja Simic-Ogrizovic, Jasmina Mimic-Oka, D. Radivojevic |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Antioxidant medicine.medical_treatment medicine.disease_cause Gastroenterology Lipid peroxidation chemistry.chemical_compound Internal medicine Humans Medicine chemistry.chemical_classification Transplantation business.industry Glutathione peroxidase Middle Aged Malondialdehyde Kidney Transplantation Pathophysiology Oxidative Stress chemistry Immunology Female Dismutase business Biomarkers Oxidative stress |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1432-2277 0934-0874 |
| DOI: | 10.1111/j.1432-2277.1998.tb01095.x |
| Popis: | An increased degree of oxidative stress (OS) in chronic renal failure (CRF) and a possible role of free radicals in CRF have already been described. However, data on OS after renal transplantation are scarce. The aim of the present study was to estimate the degree of OS in renal transplant patients. The study included four groups: 1) 15 haemodialysis patients (HD group), 2) 11 renal transplant patients with stable function (SF group), 3) 12 renal transplant patients with chronic biopsy-proven rejection (CR group), and 4) 10 healthy controls (C group). Markers of OS (malondialdehyde and thiol group levels) and antioxidant activity (glutathione peroxidase and Cu,Zn-superoxide dismutase) were determined in plasma and in red blood cells of all examined individuals. After successful renal transplantation a significant improvement, but not normalization, of antioxidant enzyme activities accompanied by significantly reduced lipid peroxidation were found. In the CR group the degree of OS was increased, and our results suggest that OS may be a relevant pathophysiological factor for CR development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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